A novel tool for the assessment of pain: validation in low back pain.
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...horts to capture exactly what changes in sensitivity occur, where and when [9,11,55,86,93,188,197]....
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...nerve lesion induced by virus infection or by diabetes), is the best approach or whether it might be preferable to classify neuropathic pain conditions on the basis of symptoms and signs [27,46,50] or of patterns of somatosensory abnormalities and the likely underlying mechanisms [5,6,12,54]....
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...In accordance with other trials [50] negative sensory signs were predominantly found in non-nociceptive parameters, with similar incidence for functions mediated by small fibers and spinothalamic tract neurons (CDT 40....
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...Patient reported outcomes, as well as quantitative sensory testing, or a combination of both, are beginning to be used to analyze sensory profiles in neuropathic pain patients and distinct subgroups of patients can be detected who are characterized by different specific sensory profiles (Baron et al., 2009; Bouhassira et al., 2005; Scholz et al., 2009)....
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...Because of their mechanistic diversity and different manifestations, these processes produce a complex profile or constellation of positive and negative sensory symptoms and signs, a “pain fingerprint” (Baron et al., 2009; Mahn et al., 2011; Scholz et al., 2009)....
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...Because of their mechanistic diversity and different manifestations, these processes produce a complex profile or constellation of positive and negative sensory symptoms and signs, a ‘‘pain fingerprint’’ (Baron et al., 2009; Mahn et al., 2011; Scholz et al., 2009)....
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...…testing, or a combination of both, are beginning to be used to analyze sensory profiles in neuropathic pain patients and distinct subgroups of patients can be detected who are characterized by different specific sensory profiles (Baron et al., 2009; Bouhassira et al., 2005; Scholz et al., 2009)....
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References
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...We applied Ward’s method [23] to perform a hierarchical cluster analysis on the distance matrix....
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...To compare the AUCs of ROC curves, we generated an estimated covariance matrix based on a nonparametric approach using the theory on generalized Ustatistics [30]....
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...org/), we calculated a distance matrix based on Gower’s general dissimilarity coefficient [22]....
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