A PIM-CHK1 signaling pathway regulates PLK1 phosphorylation and function during mitosis.
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References
1,707 citations
"A PIM-CHK1 signaling pathway regula..." refers background in this paper
...CHK1 knockout mice are embryonic lethal (Lam et al., 2004; Liu et al., 2000), and Chk1+/– mice exhibit hematopoietic defects (Boles et al., 2010)....
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...CHK1deficient blastocysts and embryonic stem cells also show severe proliferation defects as well as an impaired cell cycle checkpoint response (Liu et al., 2000; Takai et al., 2000)....
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...CHK1 knockout mice are embryonic lethal (Lam et al., 2004; Liu et al., 2000), and Chk1 mice exhibit hematopoietic defects (Boles et al....
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...CHK1deficient blastocysts and embryonic stem cells also show severe proliferation defects as well as an impaired cell cycle checkpoint response (Liu et al., 2000; Takai et al., 2000)....
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664 citations
"A PIM-CHK1 signaling pathway regula..." refers background in this paper
...Mac urek, L., Lindqvist, A., Lim, D., Lampson, M. A., Klompmaker, R., Freire, R., Clouin, C., Taylor, S. S., Yaffe, M. B. and Medema, R. H. (2008)....
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...Since STK10, SLK and Aurora A have also been previously characterized as direct mediators of PLK1 phosphorylation at T210 (Walter et al., 2003; Mac urek et al., 2008; Seki et al., 2008), it remains to be clarified how these different kinases coordinate their activities to phosphorylate and activate PLK1....
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...Since STK10, SLK and Aurora A have also been previously characterized as direct mediators of PLK1 phosphorylation at T210 (Walter et al., 2003; Mac urek et al., 2008; Seki et al., 2008), it remains to be clarified how these different kinases coordinate their activities to phosphorylate and activate…...
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574 citations
"A PIM-CHK1 signaling pathway regula..." refers background in this paper
...…STK10, SLK and Aurora A have also been previously characterized as direct mediators of PLK1 phosphorylation at T210 (Walter et al., 2003; Mac urek et al., 2008; Seki et al., 2008), it remains to be clarified how these different kinases coordinate their activities to phosphorylate and activate PLK1....
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572 citations
"A PIM-CHK1 signaling pathway regula..." refers methods in this paper
...For these experiments, costaining was performed with an antibody against PLK1, a wellestablished marker of the different mitotic steps (Strebhardt, 2010)....
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521 citations
"A PIM-CHK1 signaling pathway regula..." refers background in this paper
...CHK1deficient blastocysts and embryonic stem cells also show severe proliferation defects as well as an impaired cell cycle checkpoint response (Liu et al., 2000; Takai et al., 2000)....
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...CHK1deficient blastocysts and embryonic stem cells also show severe proliferation defects as well as an impaired cell cycle checkpoint response (Liu et al., 2000; Takai et al., 2000)....
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