A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer.
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The value of an inflammation-based prognostic score (Glasgow Prognostic score, GPS) was compared with performance status (ECOG-ps) in a longitudinal study of patients with inoperable non-small-cell lung cancer, and only the GPS was a significant predictor of survival.Abstract:
The value of an inflammation-based prognostic score (Glasgow Prognostic score, GPS) was compared with performance status (ECOG-ps) in a longitudinal study of patients (n=101) with inoperable non-small-cell lung cancer (NSCLC). At diagnosis, stratified for treatment, only the GPS (HR 2.32, 95% CI 1.52–3.54, P<0.001) was a significant predictor of survival. In contrast, neither the GPS nor ECOG-ps measured at 3–6 months follow-up were significant predictors of residual survival. This study confirms the prognostic value of the GPS, at diagnosis, in patients with inoperable NSCLC. However, the role of the GPS and ECOG-ps during follow-up has not been established.read more
Citations
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The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer.
TL;DR: The GPS/mGPS is the most extensively validated of the systemic inflammation-based prognostic scores and therefore may be used in the routine clinical assessment of patients with cancer and provides a well defined therapeutic target for future clinical trials.
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Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature
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Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer.
TL;DR: The results of the present study indicate that the GPS, before surgery, predicts overall and cancer-specific survival after resection of colon and rectal cancer.
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Evaluation of an inflammation-based prognostic score (GPS) in patients with metastatic breast cancer
TL;DR: In this paper, the authors evaluated the value of an inflammation-based score (Glasgow Prognostic Score, GPS) in patients with metastatic breast cancer, which was constructed as follows: patients with both an elevated C-reactive protein (>10mg) and hypoalbuminaemia (<35g) were allocated a score of 2.
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Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer.
TL;DR: Preoperative Glasgow prognostic score is considered to be a useful predictor of postoperative mortality in patients with colorectal cancer.
References
More filters
Journal ArticleDOI
A new international staging system for lung cancer
TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
Journal ArticleDOI
The new International Staging System for Lung Cancer.
TL;DR: The International Staging System for Lung Cancer provides for classification of six levels of disease extent in five stage groups that relate to patient management and prognosis and can be readily applied in a broad spectrum of clinical and teaching environments.
Journal ArticleDOI
Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer.
TL;DR: A score based on the combination of the systemic inflammatory response and albumin hazards ratio (HR) was comparable in prognostic value to that based on stage and performance status in patients with inoperable non-small-cell lung cancer.
Journal ArticleDOI
Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss.
Donald C. McMillan,Walter S. Watson,Patricia O'Gorman,Tom Preston,Hazel R. Scott,Colin S. McArdle +5 more
TL;DR: The interrelationship between albumin, body cell mass, and the inflammatory response is consistent with the concept that the presence of an ongoing inflammatory response contributes to the progressive loss of these vital protein components of the body and the subsequent death of patients with advanced cancer.
Journal ArticleDOI
Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer.
TL;DR: The value of an inflammation-based prognostic score was compared with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer and only the GPS was a significant independent predictor of survival.