A rapid esterification by means of mixed anhydride and its application to large-ring lactonization.
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In this paper, a rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed.Abstract:
A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including DL-2,4,6-tridemethyl-3-deoxymethynolide.read more
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Palladium-catalyzed cross-coupling reactions in total synthesis.
TL;DR: In this Review, highlights of a number of selected syntheses are discussed, demonstrating the enormous power of these processes in the art of total synthesis and underscore their future potential in chemical synthesis.
Journal ArticleDOI
Palladiumkatalysierte Kreuzkupplungen in der Totalsynthese
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,Paul G. Bulger,Paul G. Bulger,David Sarlah,David Sarlah +5 more
TL;DR: In this paper, the authors discuss the effect of leistungsfahigen Reaktionen on the Potenzial f f zukunftige chemischen Synthesen unterstreichen, i. e.g., palladiumkatalysierten Kreuzkupplungen.
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Macrolactonizations in the Total Synthesis of Natural Products
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Scandium Trifluoromethanesulfonate as an Extremely Active Lewis Acid Catalyst in Acylation of Alcohols with Acid Anhydrides and Mixed Anhydrides.
TL;DR: The method presented is especially effective for selective macrolactonization of omega-hydroxy carboxylic acids.
Journal ArticleDOI
An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: A powerful and convenient mixed anhydride method promoted by basic catalysts
TL;DR: In this article, the authors used 2-methyl-6-nitrobenzoic anhydride with triethylamine as a basic catalyst for the condensation reaction.
References
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Journal ArticleDOI
Synthesis of macrolides
TL;DR: The macrolide class of natural products, although known for some time, has until recently received little synthetic attention as discussed by the authors, mainly due to the lack of general synthetic methodology and the complex structures involved, but in recent years has changed with the development of new experimental techniques.
Journal ArticleDOI
Macrolides. Recent progress in chemistry and biochemistry.
TL;DR: This review attempts to cover the important contributions which have been made in the fields of structural and synthetic chemistry as well as in the biosynthesis and mode of antimicrobial activity of the “polyoxo” macrolide antibiotics.
Journal ArticleDOI
The synthesis of macrocyclic lactones: Approaches to complex macrolide antibiotics
Journal ArticleDOI
Activation of thiol esters. Partial synthesis of cytochalasins A and B
TL;DR: Bei Aktivierung der Thiolester (I) mit Hg(II)-Salzen in Gegenwart von tert.-Butanol (II) erfolgt S -+ O-Ester-Umwandlung zu den Produkten (III).
Journal ArticleDOI
Vielgliedrige heterocyclische Verbindungen VIII. Zur Kenntnis der hochgliedrigen Mono‐ und Poly‐lȧctonringe
TL;DR: In this article, the authors showed, dass die Veresterungsreaktion entgegenlaufende Verseifungs reaktion keine messbare Geschwindigkeit besitzt.
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