A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology.
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TLDR
Novel insight is provided into the role of the hippocampus and the effects of APP overexpression on memory and search behaviour in an open‐field foraging task in PDAPP mice.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2018-03-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Working memory.read more
Figures
Table 5. Table showing the mean (and SEM) of the number of perseverative errors and chaining responses in the foraging task made by HPC lesion mice (n=11) and SHAM controls (n=13; Experiment 1 and 2) and WT (n=15) and PDAPP mice (n=14; Experiment 3). Numbers in bold represent significant differences in between group comparisons. 
Figure 3: Foraging behaviour in control mice and mice with HPC lesions. Measures of SWM in SHAM control (n=13) and HPC lesion mice (n=11). A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. *p<0.05. Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. 
Figure 2. Reconstruction of the minimal (A) and maximal (B) extent of bilateral hippocampal lesions through coronal sections through the brain. Coordinates represent distance from bregma in mm. 
Figure 4: Foraging behaviour in mice with HPC lesions. Measures of SWM in SHAM control (n=13) and HPC lesion mice (n=11). A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. **p<0.01. Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. 
Figure 5: Foraging behaviour and SWM performance in PDAPP (n=14) and WT control mice (n=15). Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. *p<0.05
Citations
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Journal ArticleDOI
ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease
Charles E. Evans,James Scott Miners,Giulia Piva,Christine L. Willis,David M. Heard,Emma Jane Kidd,Mark Andrew Good,Patrick G. Kehoe +7 more
TL;DR: In this article, diminazene aceturate (DIZE), an established activator of ACE2, was shown to reduce hippocampal Aβ and restore cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice.
Journal ArticleDOI
The cognitive control of eating and body weight: it's more than what you "think"
TL;DR: Evidence is reviewed that consuming a WD is associated with the emergence of pathophysiologies in the hippocampus, an important brain substrate for learning, memory, and cognition, and how eating a WD could impair hippocampal function, producing cognitive deficits that promote increased WD intake and body weight gain.
Journal ArticleDOI
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease.
Paula Maria Quaglio Bellozi,Giovanni Freitas Gomes,Maria Carolina Machado da Silva,Isabel Vieira de Assis Lima,Carla R.A. Batista,Wellerson de Oliveira Carneiro Junior,Juliana G. Doria,Érica Leandro Marciano Vieira,Rafael P. Vieira,Rossimiriam Pereira de Freitas,Cláudia N. Ferreira,Eduardo Candelario-Jalil,Tony Wyss-Coray,Fabiola M. Ribeiro,Antônio Carlos Pinheiro de Oliveira +14 more
TL;DR: Despite a four-week treatment did not prevent memory loss in aged transgenic mice, CDPPB possess is protective against Aβ stimulus, therefore, this drug represents a potential candidate for further investigations as AD treatment.
Journal ArticleDOI
Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.
TL;DR: In this article, a review assesses several Alzheimer's disease mouse models from the aspect of biomarkers and cognitive impairment and discusses their potential as tools to provide novel AD therapeutic approaches, but none of these models exhibit all pathologies present in human AD.
Journal ArticleDOI
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.
Charles E. Evans,Rhian S. Thomas,Thomas J. Freeman,Martha Hvoslef-Eide,Mark Andrew Good,Emma Jane Kidd +5 more
TL;DR: An antibody, 2B3, is used that binds to APP at the BACE cleavage site, inhibiting Aβ production and improves memory for object-in-place associations and working memory in a foraging task in PDAPP mice and WT mice.
References
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John A. Walker,David S. Olton +1 more
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Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.
Salvador Huitron-Resendiz,Manuel Sanchez-Alavez,Roger A. Gallegos,Greta I. Berg,Elena Crawford,Jeannie L. Giacchino,Dora Games,Steven J. Henriksen,José R. Criado +8 more
TL;DR: It is suggested that PDAPP mice exhibit age-independent and age-related deficits in neural mechanisms regulating visuospatial learning, the total amount and the circadian distribution of sleep-wake states, thermoregulation and motor activity.
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Selective Lesions of the Dentate Gyrus Produce Disruptions in Place Learning for Adjacent Spatial Locations
TL;DR: Findings provide further support for a critical role for the dDG in spatial pattern separation by demonstrating the importance of a processing mechanism that is capable of reducing interference among overlapping spatial inputs across a variety of memory demands.
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Perseveration on place reversals in spatial swimming pool tasks: Further evidence for place learning in hippocampal rats
Ian Q. Whishaw,Jo-Anne Tomie +1 more
TL;DR: Two experiments provide further evidence for place learning in hippocampal rats and show that perseverative responses contribute to impairments in new learning.