A rapidly acquired foraging-based working memory task, sensitive to hippocampal lesions, reveals age-dependent and age-independent behavioural changes in a mouse model of amyloid pathology.
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TLDR
Novel insight is provided into the role of the hippocampus and the effects of APP overexpression on memory and search behaviour in an open‐field foraging task in PDAPP mice.About:
This article is published in Neurobiology of Learning and Memory.The article was published on 2018-03-01 and is currently open access. It has received 7 citations till now. The article focuses on the topics: Working memory.read more
Figures
Table 5. Table showing the mean (and SEM) of the number of perseverative errors and chaining responses in the foraging task made by HPC lesion mice (n=11) and SHAM controls (n=13; Experiment 1 and 2) and WT (n=15) and PDAPP mice (n=14; Experiment 3). Numbers in bold represent significant differences in between group comparisons. 
Figure 3: Foraging behaviour in control mice and mice with HPC lesions. Measures of SWM in SHAM control (n=13) and HPC lesion mice (n=11). A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. *p<0.05. Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. 
Figure 2. Reconstruction of the minimal (A) and maximal (B) extent of bilateral hippocampal lesions through coronal sections through the brain. Coordinates represent distance from bregma in mm. 
Figure 4: Foraging behaviour in mice with HPC lesions. Measures of SWM in SHAM control (n=13) and HPC lesion mice (n=11). A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. **p<0.01. Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. 
Figure 5: Foraging behaviour and SWM performance in PDAPP (n=14) and WT control mice (n=15). Data were averaged across four trials for each mouse and mean score for each group is reported. Error bars represent the S.E.M. A) Total number of errors. B) Total number of repeat errors. C) The ratio of neighbouring and distal errors to total errors made. *p<0.05
Citations
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Journal ArticleDOI
ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease
Charles E. Evans,James Scott Miners,Giulia Piva,Christine L. Willis,David M. Heard,Emma Jane Kidd,Mark Andrew Good,Patrick G. Kehoe +7 more
TL;DR: In this article, diminazene aceturate (DIZE), an established activator of ACE2, was shown to reduce hippocampal Aβ and restore cognition in mid-aged (13-14-month-old) symptomatic Tg2576 mice.
Journal ArticleDOI
The cognitive control of eating and body weight: it's more than what you "think"
TL;DR: Evidence is reviewed that consuming a WD is associated with the emergence of pathophysiologies in the hippocampus, an important brain substrate for learning, memory, and cognition, and how eating a WD could impair hippocampal function, producing cognitive deficits that promote increased WD intake and body weight gain.
Journal ArticleDOI
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease.
Paula Maria Quaglio Bellozi,Giovanni Freitas Gomes,Maria Carolina Machado da Silva,Isabel Vieira de Assis Lima,Carla R.A. Batista,Wellerson de Oliveira Carneiro Junior,Juliana G. Doria,Érica Leandro Marciano Vieira,Rafael P. Vieira,Rossimiriam Pereira de Freitas,Cláudia N. Ferreira,Eduardo Candelario-Jalil,Tony Wyss-Coray,Fabiola M. Ribeiro,Antônio Carlos Pinheiro de Oliveira +14 more
TL;DR: Despite a four-week treatment did not prevent memory loss in aged transgenic mice, CDPPB possess is protective against Aβ stimulus, therefore, this drug represents a potential candidate for further investigations as AD treatment.
Journal ArticleDOI
Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment.
TL;DR: In this article, a review assesses several Alzheimer's disease mouse models from the aspect of biomarkers and cognitive impairment and discusses their potential as tools to provide novel AD therapeutic approaches, but none of these models exhibit all pathologies present in human AD.
Journal ArticleDOI
Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice.
Charles E. Evans,Rhian S. Thomas,Thomas J. Freeman,Martha Hvoslef-Eide,Mark Andrew Good,Emma Jane Kidd +5 more
TL;DR: An antibody, 2B3, is used that binds to APP at the BACE cleavage site, inhibiting Aβ production and improves memory for object-in-place associations and working memory in a foraging task in PDAPP mice and WT mice.
References
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Journal ArticleDOI
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.
TL;DR: The intracerebral environment of the APP/PS mouse brain and postmortem brain is an unphysiological state, and more than 3000 publications based on APP andAPP/PS overexpression must be reevaluated.
Journal ArticleDOI
Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: Digital morphometric analyses
Chi-Cheng Wu,Faisal Chawla,Dora Games,Russell E. Rydel,Stephen Freedman,Dale Schenk,Warren G. Young,John H. Morrison,Floyd E. Bloom +8 more
TL;DR: It is concluded that substantial dendritic pathology is evident in 90-day-old PDAPP mice for a spatially defined subset of GCs well before amyloid accumulation occurs.
Journal ArticleDOI
Human analogue of the morris water maze for testing subjects at risk of Alzheimer's disease.
Jan Laczó,Ross Andel,Martin Vyhnalek,Kamil Vlcek,Hana Magerova,Alexandra Varjassyova,Martin Tolar,Jakub Hort +7 more
TL;DR: AMCI subjects represent a very heterogeneous population, and spatial memory or cued recall examination can add more value to aMCI classification, and ApoE4+ patients are more impaired than Apo E4– patients.
Journal ArticleDOI
Freedom of movement and the stability of its unfolding in free exploration of mice
TL;DR: This work unfettering exploration from constraints imposed by hunger, thirst, coercion, and the confines of small cage and short session, using advanced computational tools, reveals its meaning in the operational world of the mouse.
Journal ArticleDOI
Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice.
Jason K. Clark,Matthew Furgerson,Jonathon D. Crystal,Marcus Fechheimer,Ruth Furukawa,John J. Wagner +5 more
TL;DR: The early presence of this cognitive impairment and the associated alterations in synaptic plasticity demonstrate that the onset of some behavioral and neurophysiological consequences can occur before the detectable presence of plaques and tangles in the 3xTg-AD mouse model of Alzheimer's disease.