A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
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...Two distinct ghrelin receptor cDNAs have been isolated (111)....
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...Ghrelin receptor, or GHS-R, is a typical GPCR with seven transmembrane domains (7-TM) (111, 155, 218)....
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...Another GHS-R cDNA, type 1b, is produced by an alternative splicing mechanism (111)....
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...GHS-R, however, was known to bind several artificial ligands, such as GHRP-6, hexarelin, or nonpeptide GHS MK-0677, providing a convenient positive control for constructing the assay system used to search for the endogenous ligand (111, 186)....
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...Unlike other orphan GPCRs, GHS-R was known to bind artificial ligands, such as GHRP-6 or hexarelin, providing a convenient positive control for any screening assay (111, 186)....
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