Abstract: This is a free sample of content from Signaling by Receptor Tyrosine Kinases Click here for more information or to buy the book. This is a free sample of content from Signaling by Receptor Tyrosine Kinases Click here for more information or to buy the book. Front cover artwork: Stylized representations of the 20 different receptor tyrosine kinase (RTK) families found in humans—accounting for a total of 58 different receptors. The common intra-cellular tyrosine kinase domain (lower part of each receptor) is shown as a red rectangle. Domains in the extracellular region (upper part of each receptor) are much more variable across families and include immunoglobulin domains (blue), fibronectin type III domains (orange), and many others. The chapters in this volume describe mechanisms by which ligand binding to the extracellular region controls activity of the intracellular kinase domain, which vary substantially across the family and drive a variety of intracellular signaling pathways. All World Wide Web addresses are accurate to the best of our knowledge at the time of printing. Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Cold Spring Harbor Laboratory Press, provided that the appropriate fee is paid directly to the Copyright Clearance Center (CCC). Write or call CCC at 222 Rosewood Drive, Danvers, MA 01923 (978-750-8400) for information about fees and regulations. Prior to photocopying items for educational classroom use, contact CCC at the above address. Additional information on CCC can be obtained at CCC Online at www.copyright.com.
