FIGURE 8: Dependence of the activity of human tPA (Va) on [Pg]. (1) The reaction was performed with 3.3× 10-4 µM tPA in the absence of fibrinogen fragments. The solid curveVa ) 0.0005Pg/ (4.5 + Pg) represents the best fit; see model 2. The dashed lineVa ) 0.0001Pg is shown as an example of an alternative fit. (2) The reaction was performed under the same conditions but in the presence of fibrinogen fragments. The solid curveVa ) 0.0085Pg/ (0.1 + Pg) represents the best fit; see model 3.
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