Journal ArticleDOI
A renaissance for SRC
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TLDR
A key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.Abstract:
The c-SRC non-receptor tyrosine kinase is overexpressed and activated in a large number of human malignancies and has been linked to the development of cancer and progression to distant metastases. These observations have led to the recent targeting of c-SRC for the development of anticancer therapeutics, which show promise as a new avenue for cancer treatment. Despite this, however, the precise functions of c-SRC in cancer remain unclear. In addition to increasing cell proliferation, a key role of c-SRC in cancer seems to be to promote invasion and motility, functions that might contribute to tumour progression.read more
Citations
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Molecular requirements for epithelial-mesenchymal transition during tumor progression.
TL;DR: Increasing evidence suggests that EMT plays a specific role in the migration of cells from a primary tumor into the circulation and may provide a rationale for developing more effective cancer therapies.
Journal ArticleDOI
The Epidermal Growth Factor Receptor Pathway: A Model for Targeted Therapy
Maurizio Scaltriti,José Baselga +1 more
TL;DR: Recent advances in understanding in the mechanisms of receptor activation and function, discovery of primary and secondary EGFR somatic mutations, as well as a new generation of anti-EGFR agents provide new leads on the clinical targeting of this receptor.
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The LIR motif - crucial for selective autophagy.
TL;DR: Comment on new insights on the interactions of LIR-containing proteins with members of the ATG8 protein family on the interaction of autophagy receptors to LC3-interacting region proteins anchored in the phagophore membrane.
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The Blood-Testis Barrier and Its Implications for Male Contraception
C. Yan Cheng,Dolores D. Mruk +1 more
TL;DR: Multiple potential targets are present at the BTB for innovative contraceptive development and for better delivery of drugs to alleviate toxicant-induced reproductive dysfunction in men, as well as critically evaluate findings in the field regarding studies on drug transporters in the testis.
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Src kinases as therapeutic targets for cancer
TL;DR: Small-molecule SFK inhibitors have been developed and are undergoing early phase clinical testing and seem to be safe in humans and could add to the therapeutic arsenal against subsets of cancers.
References
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Cell Migration: A Physically Integrated Molecular Process
TL;DR: The authors are grateful for financial support from the National Institutes of Health (grants GM23244 and GM53905), and to very helpful comments on the manuscript from Elliot Elson, Vlodya Gelfand, Paul Matsudaira, Julie Theriot, and Sally Zigmond.
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William C. Hahn,William C. Hahn,Christopher M. Counter,Ante S. Lundberg,Ante S. Lundberg,Roderick L. Beijersbergen,Mary W. Brooks,Robert A. Weinberg +7 more
TL;DR: It is shown that the ectopic expression of the telomerase catalytic subunit (hTERT) in combination with two oncogenes results in direct tumorigenic conversion of normal human epithelial and fibroblast cells.
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The STATs of cancer — new molecular targets come of age
Hua Yu,Richard Jove +1 more
TL;DR: Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance, and STAT proteins — especially STAT3 and STAT5 — regulate all of these processes and are persistence activated in a surprisingly large number of human cancers.
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Transforming gene product of Rous sarcoma virus phosphorylates tyrosine
TL;DR: It is inferred that pp60src is a novel protein kinase and that the modification of proteins via the phosphorylation of tyrosine is essential to the malignant transformation of cells by Rous sarcoma virus.