Journal ArticleDOI
A response-adaptive design in crossover trial
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In this article, an adaptive allocation rule for a two-treatment two-period crossover design in the presence of possible carryover effects was proposed, which is a combination of the play-the-winner and randomized playthewinner rules.Abstract:
In the present work, whenever the response variables are binary, we frame an adaptive allocation rule for a two-treatment two-period crossover design in the presence of possible carry-over effects. The proposed rule is a combination of the play-the-winner and randomized play-the-winner rules. We study various properties of the proposed rule through asymptotics and simulations. Some related inferential problems are also considered. The proposed procedure is compared with some possible competitor.read more
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Journal ArticleDOI
Serial correlation in the design and analysis of crossover trials
Journal ArticleDOI
Multiple-objective response-adaptive repeated measurement designs in clinical trials for binary responses
TL;DR: This work extends the allocation strategy developed for continuous responses to constructing response-adaptive repeated measurement designs for binary responses and finds that it can successfully allocate more patients to better treatment sequences without sacrificing much estimation precision.
References
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Book
analysis of binary data
David Cox,E. J. Snell +1 more
TL;DR: Binary response variables special logistical analyses some complications some related approaches more complex responses.
Book
Order restricted statistical inference
TL;DR: In this paper, a set of multinomial parameters are derived about distributions subject to shape restrictions, and a conditional expectation given a sigma-lattice is given in a more general setting.
Book
Theory of rank tests
TL;DR: In this article, the authors present an elementary theory of rank tests and a set of properties of rank estimators, including asymptotic optimality and efficiency, as well as non-null distributions.