A review on bioactive secondary metabolites reported from actinomycetes isolated from marine soil samples of indian peninsula

TL;DR: The antimicrobial (antibacterial-ESBL, MRSA, VRE, antidermatophytic and anticandidal) and anticancer secondary metabolites reported from actinomycetes reported from Indian Peninsula are summarized.

Abstract: The aim of this review is to give an update on actinobacteria derived bioactive secondary metabolites reported from Indian Peninsula. Several research groups in India are working on actinomycetes diversityand focusing more on antimicrobial, antiparasitic, anticancer activity and enzymes produced by these species. Several reports are available on multiple biological activitiesof culture filtrate/crude extracts obtained from actinomycetes isolates. Bioactivity guided extraction, purification andcompound identification has yielded several novel compounds. Scalable production of bioactive compounds from potential actinomycetes is under different phases of clinical trials for drug development as antibiotics worldwide. Currently actinomycetes research is more intense and more predominant not only in India but throughout the world due to its well-known ability to produce novel antibiotics and new chemical entities. The demand for new antibiotics from marine actinomycetes to overcome microbial drug resistance and to develop a new anticancer drug leads is ever persistent. Several novel antibiotics and anticancer metabolites are already been reported from actinomycetes in the recent past. In this review the bioactive compounds reported from marine actinomycetes species isolated from samples collected at various locations of Indian Peninsula has been reviewed.. The focus of the present review is to summarize the antimicrobial (antibacterial-ESBL, MRSA, VRE, antidermatophytic and anticandidal) and anticancer secondary metabolites reported from actinomycetes.