Fig. 4. PdSP15 is an odorant-binding protein in saliva of phlebotomine sand flies. (A) Phylogenetic tree analysis shows the similarity of odorant-binding proteins in New and Old World sand fly species and their divergence from odorant-binding proteins (OBP) of other dipterans and humans. Bootstrap value, 10,000. PdSP15 location is underlined in red. (B) Sequence alignment between PdSP15 from P. duboscqi (accession number 112361953) and its orthologs in P. papatasi (PpSP15, accession number 449060564) and P. sergenti (PsSP15, accession number 299829414). Black shading and gray shading represent identical and similar amino acids, respectively. (C) Crystal structure of PdSP15 (4OZD) containing six a-helical elements designated as a, c, d, e, f, and g.
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