A serum circulating miRNA diagnostic test to identify asymptomatic high‐risk individuals with early stage lung cancer
Fabrizio Bianchi,Francesco Nicassio,Matteo Jacopo Marzi,Elena Belloni,Valentina Dall'Olio,Loris Bernard,Giuseppe Pelosi,Patrick Maisonneuve,Giulia Veronesi,Pier Paolo Di Fiore,Pier Paolo Di Fiore +10 more
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TLDR
A test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non‐small cell lung carcinomas (NSCLCs) in a population of asymptomatic high‐risk individuals with 80% accuracy is developed.Abstract:
Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC.read more
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MicroRNA: function, detection, and bioanalysis.
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Global Epidemiology of Lung Cancer
TL;DR: The evidence on lung cancer epidemiology, including data of international scope with comparisons of economically, socially, and biologically different patient groups is reviewed, including a discussion on the epidemiologic characteristics of special groups including women and nonsmokers.
Journal ArticleDOI
MicroRNA (miRNA) in cancer
TL;DR: This review summarizes: (i) the current understanding of interactions between miRNAs and their target genes, (ii) recent advances in the regulatory mechanisms that control the expression of genes related to carcinogenesis, and (iii) the role of mi RNAs in cancer diagnosis and therapy.
Journal ArticleDOI
Evaluation of Tumor-Derived Exosomal miRNA as Potential Diagnostic Biomarkers for Early-Stage Non–Small Cell Lung Cancer Using Next-Generation Sequencing
Xiance Jin,Yanfan Chen,Hanbin Chen,Shaoran Fei,Didi Chen,Xiaona Cai,Linger Liu,Baochai Lin,Huafang Su,Lihao Zhao,Meng Su,Huanle Pan,Lanxiao Shen,Deyao Xie,Congying Xie +14 more
TL;DR: Tumor-derived exosomal miRNAs, adenocarcinoma-specific miR-181-5p, mi-30a-3p,miR-30e- 3p and mi-361- 5p are identified and may be promising and effective candidates in the development of highly sensitive, noninvasive biomarkers for early NSCLC diagnosis.
Journal ArticleDOI
Clinical Applications for microRNAs in Cancer
S P Nana-Sinkam,Carlo M. Croce +1 more
TL;DR: An increased understanding of fundamental miRNA biology, improved bioinformatics, and directed in vivo targeting while minimizing off‐target effects and toxicity will be required for successful translational application.
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