A simple approach to highly functionalized benzo[b]furans from phenols and aryl iodides via aryl propargyl ethers
TL;DR: In this paper, a variety of mono-and disubstituted phenols are alkylated with propargyl bromide to give phenyl 2-propynyl ethers, which were further coupled with aryl iodides under Sonogashira reaction conditions to give 3-phenoxy-1-aryl-1propyne derivatives.
About: This article is published in Tetrahedron Letters.The article was published on 2008-06-30. It has received 37 citations till now. The article focuses on the topics: Propargyl bromide & Aryl.
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TL;DR: In this article, the authors presented numerous useful processes for the synthesis of heterocycles, which involve palladium-catalyzed coupling followed by heteroannulation reactions, reported in recent years.
156 citations
TL;DR: An iron-catalyzed intramolecular alkyne-aldehyde metathesis strategy of the alkynyl ether of salicylaldehyde derivatives has been developed which works under mild reaction conditions to produce the functionalized 2H-chromene derivatives.
Abstract: An iron-catalyzed intramolecular alkyne−aldehyde metathesis strategy of the alkynyl ether of salicylaldehyde derivatives has been developed which works under mild reaction conditions to produce the functionalized 2H-chromene derivatives. This protocol is compatible toward a wide range of functional groups, such as methoxy, fluoro, chloro, bromo, and phenyl groups. This method provides an atom-economical and environmentally friendly approach for the synthesis of a series of substituted 2H-chromenes.
106 citations
TL;DR: In this article, the authors highlight the recent advances in the synthetic approaches to this important heterocyclic system and wide variety of its derivatives, including derivatives extracted from coal tar and converted into a synthetic resin, used in different industries.
Abstract: Benzofuran itself is an oily chemical compound, extracted from coal tar, which is converted into a synthetic resin, used in different industries. Several derivatives of benzofuran occur naturally in some plants and are the scaffold in several natural products. However, most of them are synthesized via different synthetic routes. In this chapter, we try to highlight the recent advances in the synthetic approaches to this important heterocyclic system and wide variety of its derivatives.
68 citations
TL;DR: In this article, a host-guest complexation between an alkane functionalized with triazole moieties and three pillar[5]arenes was studied, and three column-based [2]rotaxanes were constructed based on this new recognition motif.
64 citations
TL;DR: A diphenylphosphinoyl radical-initiated sequential reaction of 1,4-diaryl-1-butynes and analogues is developed for the synthesis of 2-phosph inoylated 3, 4-dihydronaphathalenes and related compounds.
Abstract: A diphenylphosphinoyl radical-initiated sequential reaction of 1,4-diaryl-1-butynes and analogues is developed for the synthesis of 2-phosphinoylated 3,4-dihydronaphathalenes and related compounds.
60 citations
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4,417 citations
TL;DR: Transition-Metal-Free Reactions, Alkynylation of Heterocycles, and Synthesis of Electronic and Electrooptical Molecules: A Review.
Abstract: 3.7. Palladium Nanoparticles as Catalysts 888 3.8. Other Transition-Metal Complexes 888 3.9. Transition-Metal-Free Reactions 889 4. Applications 889 4.1. Alkynylation of Arenes 889 4.2. Alkynylation of Heterocycles 891 4.3. Synthesis of Enynes and Enediynes 894 4.4. Synthesis of Ynones 896 4.5. Synthesis of Carbocyclic Systems 897 4.6. Synthesis of Heterocyclic Systems 898 4.7. Synthesis of Natural Products 903 4.8. Synthesis of Electronic and Electrooptical Molecules 906
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TL;DR: This account describes 275 new isoflavonoids published between 2008 and 2011 as constituents of the Leguminosae, commenting on their source, identification, biological activity, synthesis, and ecological or chemosystematic significance.
260 citations