A Simple, Efficient and Green Procedure for the Knoevenagel Condensation of Aldehydes with N-Methylpiperazine at Room Temperature under Solvent-Free Conditions
TL;DR: In this article, Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions.
About: This article is published in Synthetic Communications.The article was published on 2008-08-18. It has received 35 citations till now. The article focuses on the topics: Knoevenagel condensation & Malononitrile.
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TL;DR: A facile and efficient method for the preparation of allyl amides from the aldehyde of Baylis–Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition.
Abstract: Herein, a facile and efficient method for the preparation of allyl amides from the aldehyde of Baylis–Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition. The effects of solvents and temperature on the reaction and substituents on the phenyl ring have been examined. This method is best demonstrated by its advantages such as operational simplicity, moderate to excellent yields, short reaction time, and simple reaction procedure. Most importantly, the reaction proceeds smoothly in the absence of a catalyst and an external oxidant.
10 citations
TL;DR: In this paper, a simple and clean synthesis of polysubstituted 2,6-dicyanoanilines has been developed via the reaction of arylidenemalonodinitriles with 1-arylethylidenmalonoditriles in ethanol catalyzed by KF/ alumina.
Abstract: A simple and clean synthesis of polysubstituted 2,6-dicyanoanilines has been developed via the reaction of arylidenemalonodinitriles with 1-arylethylidenemalonodinitriles in ethanol catalyzed by KF/ alumina. Use of non-hazardous solid base as a catalyst, operational simplicity and improved product yields are the key advantages of the present protocol.
10 citations
TL;DR: In this paper, surface functionalization of SBA-15 followed by its reaction with manganese acetate has been carried out to develop a new Mn-grafted functionalized mesoporous material.
Abstract: Surface functionalization of SBA-15 followed by its reaction with manganese acetate has been carried out to develop a new Mn-grafted functionalized mesoporous material and it was characterized by powder X-ray diffraction (XRD), BET nitrogen adsorption–desorption, IR spectroscopy, transmission electron microscopy and diffuse reflectance UV–Vis spectroscopy. The XRD and TEM analyses showed that textural properties of SBA-15 were retained during the grafting procedure and after five-time recycling. The resulting material was successfully applied as a heterogeneous catalyst for Knoevenagel condensation in good to excellent yields under mild conditions.
8 citations
TL;DR: Al(III)/ZrO 2 with 5-25% Al(III) was coated on honeycomb monoliths by dip & dry technique and were also prepared in their powder forms for the purpose of comparison as mentioned in this paper.
8 citations
References
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TL;DR: This paper presents a new approach to solvent-free organic synthesis called “Solvent-free synthesis with real-time stoichiometry” that combines high-performance liquid chromatography and high-tech electronics.
Abstract: Solvent-free organic synthesis , Solvent-free organic synthesis , کتابخانه دیجیتال جندی شاپور اهواز
1,004 citations
Book•
01 Jan 2003TL;DR: In this paper, the authors proposed a Solvent Free Organic Synthesis (SOS) method for organic synthesis, which is a state-of-the-art method for solvent-free organic synthesis.
Abstract: Solvent-free organic synthesis , Solvent-free organic synthesis , کتابخانه دیجیتال جندی شاپور اهواز
828 citations
337 citations
TL;DR: In this article, the knoevenagel condensation of carbonyl substrates with acidic methylene reagents proceeds smoothly in presence of zinc chloride, without the need for solvent, to produce products of good purity in high yield.
268 citations
Journal Article•
TL;DR: In this article, the authors proposed a methodology for condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature.
Abstract: The basic ionic liquid 1-butyl-3-methylimidazolium hydroxide, [bmIm]OH, efficiently catalyzes Knoevenagel condensation without requirement of any organic solvent. A wide range of aliphatic and aromatic aldehydes and ketones easily undergo condensations with diethyl malonate, malononitrile, ethyl cyanoacetate, malonic acid and ethyl acetoacetate. The reactions proceed at room temperature and are very fast (10-30 min). However, the most significant feature of this methodology is the condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature providing a general and convenient procedure.
204 citations