A Simple, Efficient and Green Procedure for the Knoevenagel Condensation of Aldehydes with N-Methylpiperazine at Room Temperature under Solvent-Free Conditions
TL;DR: In this article, Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions.
About: This article is published in Synthetic Communications.The article was published on 2008-08-18. It has received 35 citations till now. The article focuses on the topics: Knoevenagel condensation & Malononitrile.
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TL;DR: In this paper, the influence of synthesis conditions on the purity of the AlPO4-5 has been studied by changing Al sources and factors affecting the pH of the starting gel.
Abstract: Hydrothermal synthesis of pure AlPO4-5 crystals using various reaction gels is reported. The influence of synthesis conditions on the purity of the AlPO4-5 has been studied by changing Al sources and factors affecting the pH of the starting gel. It was observed that the additive acid to adjust the gel pH value has strongly influenced both the crystallinity and purity of the resulting AlPO4-5 crystals. The crystals were characterized by XRD, FT-IR, TGA, BET, SEM and TPD techniques. The resulting microporous AlPO4-5 was used as an efficient support for a functional polymer to produce an efficient heterogeneous basic nanocomposite catalyst. The catalytic activity of this novel nanocomposite was tested for Knoevenagel reaction under solvent-free conditions at room temperature. The catalyst showed a considerable degree of reusability besides very good activity.
7 citations
TL;DR: An efficient method for the construction of carbon-carbon double bond has been developed from aromatic aldehydes and compounds with active methylene moieties in the presence of catalytic amount of solid sodium ethoxide via mechanochemical approach.
Abstract: An efficient method for the construction of carbon–carbon double bond has been developed from aromatic aldehydes and compounds with active methylene moieties in the presence of catalytic amount of solid sodium ethoxide via mechanochemical approach. This capable process provides a diverse range of homoaryl/heteroaryl/aliphatic acrylates and nitriles in good to excellent yields at short reaction period.
5 citations
TL;DR: In this paper , a magnetic nanocatalyst of tertiary amine ionic liquid incorporated Fe3O4 was prepared and applied in the Knoevenagel reaction, the catalyst exhibits good stability and excellent catalytic performance in the KG reaction, short reaction time and excellent yields of KG products.
5 citations
07 Mar 2019
4 citations
TL;DR: In this paper, a condensation of 2-chloroacetate with the hydroxy group of 2amino-8-hydroxy-4-phenethyl-4...
Abstract: Ethyl 2-[(2-amino-3-cyano-4-phenethyl-4H-naphtho[1,2-b]pyran-8-yl)oxy]acetate has been synthesised by condensation of ethyl 2-chloroacetate with the hydroxy group of 2-amino-8-hydroxy-4-phenethyl-4...
4 citations
References
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TL;DR: This paper presents a new approach to solvent-free organic synthesis called “Solvent-free synthesis with real-time stoichiometry” that combines high-performance liquid chromatography and high-tech electronics.
Abstract: Solvent-free organic synthesis , Solvent-free organic synthesis , کتابخانه دیجیتال جندی شاپور اهواز
1,004 citations
Book•
01 Jan 2003TL;DR: In this paper, the authors proposed a Solvent Free Organic Synthesis (SOS) method for organic synthesis, which is a state-of-the-art method for solvent-free organic synthesis.
Abstract: Solvent-free organic synthesis , Solvent-free organic synthesis , کتابخانه دیجیتال جندی شاپور اهواز
828 citations
337 citations
TL;DR: In this article, the knoevenagel condensation of carbonyl substrates with acidic methylene reagents proceeds smoothly in presence of zinc chloride, without the need for solvent, to produce products of good purity in high yield.
268 citations
Journal Article•
TL;DR: In this article, the authors proposed a methodology for condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature.
Abstract: The basic ionic liquid 1-butyl-3-methylimidazolium hydroxide, [bmIm]OH, efficiently catalyzes Knoevenagel condensation without requirement of any organic solvent. A wide range of aliphatic and aromatic aldehydes and ketones easily undergo condensations with diethyl malonate, malononitrile, ethyl cyanoacetate, malonic acid and ethyl acetoacetate. The reactions proceed at room temperature and are very fast (10-30 min). However, the most significant feature of this methodology is the condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature providing a general and convenient procedure.
204 citations