A Simple, Efficient and Green Procedure for the Knoevenagel Condensation of Aldehydes with N-Methylpiperazine at Room Temperature under Solvent-Free Conditions
TL;DR: In this article, Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions.
About: This article is published in Synthetic Communications.The article was published on 2008-08-18. It has received 35 citations till now. The article focuses on the topics: Knoevenagel condensation & Malononitrile.
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TL;DR: A series of new fiber catalysts has been synthesized by aminating a commercially available polyacrylonitrile fiber with polyamines such as diethylenetriamine and triethylenetetramine as discussed by the authors.
114 citations
TL;DR: An efficient and reusable protic-ionic-liquid solvent-catalyst system, HMTA-AcOH-H2O, has been developed and used in the Knoevenagel condensation reaction of aromatic aldehydes with ethyl 2-cyanoacetate as discussed by the authors.
Abstract: An efficient and reusable protic-ionic-liquid solvent–catalyst system, HMTA–AcOH–H2O, has been developed and used in the Knoevenagel condensation reaction of aromatic aldehydes with ethyl 2-cyanoacetate. Under ultrasonic irradiation, the Knoevenagel condensation promoted by the protic-ionic-liquid solvent–catalyst system proceeds smoothly and cleanly. Moreover, the HMTA–AcOH–H2O solvent–catalyst system could be recycled for at least 6 times and no significant loss of activity was observed. This protocol has notable advantages, such as being eco-friendly, the ease of the work-up and reuse of the ionic liquid conveniently, which could help reduce disposal costs and contribute to the development of new catalysts for use in green and continuous chemical processes.
52 citations
TL;DR: In this article, an alanine functionalized MCM-41 (Alanine-MCM41) was used as a solid base catalysts for the Knoevenagel condensation of furfural and acetylacetone under solvent free condition.
36 citations
TL;DR: An efficient and facile protocol for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds with task specific ionic liquid 1,8-diazabicyclo[5.4.0]-undec-... was proposed in this paper.
Abstract: An efficient, clean and facile protocol for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalysed by task specific ionic liquid 1,8-diazabicyclo[5.4.0]-undec-...
35 citations
TL;DR: In this paper, a new silica based piperidine derivative has been designed, synthesized and characterized by solid state carbon 13 CP MAS NMR, BET surface area analysis, IR, TGA studies, elemental analysis and pH experiment.
26 citations
References
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TL;DR: Potassium exchanged layered zirconium phosphate catalyzed Knoevenagel condensation of aldehydes and active methylene compounds gave the corresponding E configurated olefinic derivatives in solvent free conditions as discussed by the authors.
27 citations
TL;DR: In this paper, an efficient and green procedure for the urea catalyzed Knoevenagel condensation was developed, in which a catalytic ammount of urea, stoichiometric aldehyde and active methylene compound reacted under solvent-free conditions at 100 °C for 5-60 min to give nearly quantitative yield of product.
Abstract: An efficient and green procedure for the urea catalyzed Knoevenagel condensation was developed. In the presence of a catalytic ammount of urea, stoichiometric aldehyde and active methylene compound reacted under solvent-free conditions at 100 °C for 5-60 min to give nearly quantitative yield of product.
27 citations
TL;DR: Creatinine was condensed with aromatic aldehydes into Z-arylidene creatinines without solvent under focused microwave irradiation as discussed by the authors, which was then used to synthesize creatinine.
26 citations
TL;DR: The Knoevenagel condensation of carbonyl compounds with active methylene compounds proceeds smoothly in presence of potassium phosphate in commercial absolute ethanol to afford the desired products as discussed by the authors.
Abstract: The Knoevenagel condensation of carbonyl compounds with active methylene compounds proceeds smoothly in presence of potassium phosphate in commercial absolute ethanol to afford the desired products...
26 citations
TL;DR: In this paper, a simple, efficient, economical, and environmentally benign method was proposed to extract α-cyanocinnamate from α-cyclic acid at room temperature.
25 citations