A single-nucleotide substitution from C to T at position -1055 in the IL-13 promoter is associated with protection from severe malaria in Thailand.
Jun Ohashi,Izumi Naka,Jintana Patarapotikul,Hathairad Hananantachai,Sornchai Looareesuwan,Katsushi Tokunaga +5 more
Reads0
Chats0
TLDR
IL-13 −1055T may show resistance to severe malaria through the alteration of IL-13 production as well as other single-nucleotide polymorphisms in the promoters of IL, IL, and IL-4 genes on the 5q31–33.Abstract:
We examined a possible association of single-nucleotide polymorphisms (SNPs) in the promoters of IL-3, IL-4, and IL-13 genes on the 5q31-33, IL-3 -16T>C, IL-4 -590T>C, and IL-13 -1055C>T, with severity of malaria in 361 adult malaria patients in Thailand. The IL-13 -1055T allele showed a significant association with protection from severe malaria (OR 0.51, 95% CI 0.32-0.80; P=0.0032 by the chi(2) test), while allele frequencies of IL-3 -16T>C and IL-4 -590T>C were not statistically different between mild and severe malaria patients. An IL-13 -1055C>T has been reported to alter the regulation of IL-13 production. Thus, IL-13 -1055T may show resistance to severe malaria through the alteration of IL-13 production.read more
Citations
More filters
Journal ArticleDOI
Th2 Cell-Selective Enhancement of Human IL13 Transcription by IL13-1112C>T, a Polymorphism Associated with Allergic Inflammation
Lisa Cameron,Robin B. Webster,Jannine M. Strempel,Patricia Kiesler,Michael Kabesch,Harikrishnan Ramachandran,Lizhi Yu,Debra A. Stern,Penelope E. Graves,I. Carla Lohman,Anne L. Wright,Marilyn Halonen,Walter T. Klimecki,Donata Vercelli +13 more
TL;DR: The findings suggest the nuclear milieu dictates the functional outcome of genetic variation in primary human and murine CD4+ Th2 lymphocytes and that increased expression of IL13-1112T in vivo may underlie its association with susceptibility to allergic inflammation.
Journal ArticleDOI
Insights into the immunopathogenesis of malaria using mouse models.
TL;DR: This review looks in detail at the processes involved in endothelial cell damage leading to syndromes such as cerebral malaria, as well as generalised systemic manifestations such as anaemia, cachexia and problems with thermoregulation of the body.
Journal ArticleDOI
Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria
E. Ayimba,Jana Hegewald,A. Y. Ségbéna,Richard G. Gantin,Christian J. Lechner,A. Agosssou,Meba Banla,Peter T. Soboslay +7 more
TL;DR: Elevated levels of proinflammatory and regulatory cytokines and chemokines were generated in infants during and after acute malaria tropica and may prove useful in evaluating either the progression or the regression of malarial disease.
Journal ArticleDOI
Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA.
Kouyuki Hirayasu,Jun Ohashi,Koichi Kashiwase,Hathairad Hananantachai,Izumi Naka,Atsuko Ogawa,Minoko Takanashi,Masahiro Satake,Kazunori Nakajima,Peter Parham,Hisashi Arase,Katsushi Tokunaga,Jintana Patarapotikul,Toshio Yabe +13 more
TL;DR: The results suggest that natural selection has reduced the frequency of the KIR2DL3-HLA-C1 combination in malaria high-endemic populations because of the propensity of interaction between KIR 2DL3 and C1 to favor development of cerebral malaria.
Journal ArticleDOI
Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia.
Philip E. Thuma,Janneke H. van Dijk,R Bucala,Zufan Debebe,Sergei Nekhai,Thea Kuddo,Mehdi Nouraie,Günter Weiss,Victor R. Gordeuk +8 more
TL;DR: Predictors of severe malarial anemia differed from those of cerebral malaria (thrombocytopenia, herbal medicine, and intravascular hemolysis), and improved preventive and therapeutic measures may need to consider these differences.
References
More filters
Journal ArticleDOI
The Interaction of Selection and Linkage. I. General Considerations; Heterotic Models.
TL;DR: The results of these investigations were sufficient to show that even for relatively simple cases (two loci, simple symmetrical selective values) linkage might have profound effects on the course of natural selection and, pari passu, natural selection may have major effect on the distribution of coupling and repulsion linkage in a population.
Journal ArticleDOI
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations
David G. Marsh,John D. Neely,Daniel R. Breazeale,Balaram Ghosh,Linda R. Freidhoff,Eva Ehrlich-Kautzky,Carsten Schou,Guha Krishnaswamy,Terri H. Beaty +8 more
TL;DR: Analysis of sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration, and a combination of segregation and maximum likelihood analyses provided further evidence.
Book
Handbook of Human Genetic Linkage
Joseph D. Terwilliger,Jurg Ott +1 more
TL;DR: "Handbook of Human Genetic Linkage" contains detailed instructions on how to carry out linkage analysis, guiding the reader through each process on a step-by-step basis.
Journal ArticleDOI
Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy
Lanny J. Rosenwasser,Dwight J. Klemm,J. Dresback,H. Inamura,James J. Mascali,Mary D. Klinnert,Larry Borish +6 more
TL;DR: Asthma may develop secondary to the transcriptional dysregulation of T lymphocyte-derived cytokines, which contains the genes for interleukins 3, 4, 5,9, 13 and gruntilocyte macrophage-colony stimulating factor (GM-CSF).
Journal ArticleDOI
Evidence for a locus regulating total serum ige levels mapping to chromosome-5
Deborah A. Meyers,Dirkje S. Postma,Carolien I.M. Panhuysen,Jianfeng Xu,PJ Amelung,Roy C. Levitt,Eugene R. Bleecker +6 more
TL;DR: Evidence for linkage of the IgE phenotype to 5q was obtained by both sib-pair and lod score analysis with evidence for recessive inheritance of high IgE levels from segregation analysis, a major step in mapping genes important in the regulation of allergic responses and the pathogenesis of asthma.
Related Papers (5)
Genome-wide and fine-resolution association analysis of malaria in West Africa
Muminatou Jallow,Yik Ying Teo,Yik Ying Teo,Kerrin S. Small,Kerrin S. Small,Kirk A. Rockett,Kirk A. Rockett,Panos Deloukas,Taane G. Clark,Taane G. Clark,Katja Kivinen,Kalifa Bojang,David J. Conway,Margaret Pinder,Giorgio Sirugo,Fatou Sisay-Joof,Stanley Usen,Sarah Auburn,Sarah Auburn,Suzannah Bumpstead,Susana Campino,Susana Campino,Alison J. Coffey,Andrew Dunham,Andrew E. Fry,Angela Green,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Anna E. Jeffreys,Alieu Mendy,Aarno Palotie,Simon C. Potter,Jiannis Ragoussis,Jane Rogers,Kate Rowlands,Elilan Somaskantharajah,Pamela Whittaker,Claire Widden,Peter Donnelly,Bryan Howie,Jonathan Marchini,Andrew P. Morris,Miguel A. Sanjoaquin,Miguel A. Sanjoaquin,Eric A. Achidi,Tsiri Agbenyega,Angela Allen,Angela Allen,Olukemi K. Amodu,Patrick H. Corran,Abdoulaye A. Djimde,Amagana Dolo,Ogobara K. Doumbo,Chris Drakeley,Sarah J. Dunstan,Jennifer Evans,Jennifer Evans,Jeremy Farrar,Deepika Fernando,Tran Tinh Hien,Rolf D. Horstmann,Muntaser E. Ibrahim,Nadira D. Karunaweera,Gilbert Kokwaro,Kwadwo A. Koram,Martha M. Lemnge,Julie Makani,Kevin Marsh,Pascal Michon,David Modiano,Malcolm E. Molyneux,Ivo Mueller,Michael Parker,Norbert Peshu,Christopher V. Plowe,Odile Puijalon,John C. Reeder,Hugh Reyburn,Eleanor M. Riley,Anavaj Sakuntabhai,Pratap Singhasivanon,Sodiomon B. Sirima,Adama Tall,Terrie E. Taylor,Mahamadou A. Thera,Marita Troye-Blomberg,Thomas N. Williams,Michael T. Wilson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +90 more