A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture
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Cites background from "A small molecule inhibitor of dengu..."
...95 μM and significant reduction of viral titers for all four serotypes at 30 μM (no cytotoxicity at 100 μM).(104) It is noteworthy that the arylcyanoacrylamide fragment reported before (compound 24, Figure 5) re-appears in 40 and 41....
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References
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"A small molecule inhibitor of dengu..." refers background in this paper
...6 billion people estimated to be at risk of dengue, ~400 million people experience dengue infections annually [4]....
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6,828 citations
Additional excerpts
...7, Schrodinger, LLC, New York, NY) as described [32]....
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1,867 citations
"A small molecule inhibitor of dengu..." refers background in this paper
...of dengue viruses (DENV-1, −2, −3 and −4) of the genus Flavivirus, family Flaviviridae, cause this disease [5]....
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...The DENV genome is a single-stranded positive sense, ~11 kilobases (Kb) long RNA molecule [5]....
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...Coand post-translational processing of this precursor by host and viral proteases generates ten viral proteins, of which three are structural and the rest, non-structural (NS) proteins [5]....
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1,732 citations
"A small molecule inhibitor of dengu..." refers background in this paper
...This is because, each of the four DENVs can cause the full spectrum of dengue disease, and all four DENV serotypes tend to co-circulate in hyperendemic regions [2,3]....
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...Dengue is an arboviral disease which is currently a very significant global public health concern [1-3]....
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1,548 citations
"A small molecule inhibitor of dengu..." refers result in this paper
...Observations that the virus titers in DHF/DSS patients are an order of magnitude higher in comparison to DF patients [14,15], suggest that a drug...
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