A smart sensor for rapid detection of lethal hydrazine in human blood and drinking water
TL;DR: In this article, the naked eye detection of hydrazine below the TLV levels, in living cells, drinking water and industrial effluents, has been demonstrated, showing good cell permeability, low cytotoxicity, fast fluorogenic recognition and good selectivity over several cation-, anion-, thiol and amine-containing compounds.
Abstract: Hydrazine exposure leads to damage of all vital organs of humans and animals, which demands the discovery of a method for the rapid and quantitative detection of hydrazine. Newly designed and synthesized receptor-bearing phenolic –OH, –Br, –CN, –ester and benzthiazole moieties displayed brilliant naked eye fluorescence sensing towards hydrazine with rapid reactivity and very good selectivity over several cation-, anion-, thiol- and amine-containing compounds. The probe showed good cell permeability, low cytotoxicity, fast fluorogenic recognition and “naked eye” detection of hydrazine below the TLV levels, in living cells, drinking water and industrial effluents.
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TL;DR: A review of existing design strategies for developing fluorescent sensors for hydrazine detection can be found in this article, where the molecular structures, sensing mechanisms and applications of these sensors were emphatically classified and discussed.
87 citations
TL;DR: A novel mitochondria-targeted ratiometric fluorescent probe (Mitro-N2H4) for N2H 4 detection and has many potential applications for imaging N 2H4 produced in situ during the metabolism of isoniazid in living cells based on the ratio of the fluorescent signal.
34 citations
TL;DR: This paper provides a review to bring more inspirations for the development of the fluorescent probes for N2H4 based on various mechanisms and different acceptor group for N 2H4.
Abstract: With the widespread use of N2H4, it brings potential risk to human health and environmental safety because of its diverse toxicological functions. In order to determine N2H4 effectively in both env...
31 citations
TL;DR: In this article, a new "turn-on" fluorescence probe, coumarin-thiophene (C-T), was designed based on PET (photo-induced electron transfer) mechanism by employing 5-chlorothiophene-2-carbonyl chloride as a electron donor and coumarins as an electron acceptor.
29 citations
TL;DR: In this paper, a donor-π-acceptor (Dπ-A) based fluorescent molecule (TPB) was synthesized for rapid and selective detection of hydrazine.
21 citations
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Book•
19 Mar 1998
TL;DR: Encyclopedia of Chemical Technology The Third Edition of the Encycled encyclopedia of chemical technology as mentioned in this paper is built on the solid foundation of the previous editions of the encyclopedia, which has been updated and updated and many new subjects have been added to reflect changes in chemical technology through the 1970s.
Abstract: Encyclopedia of Chemical Technology The Third Edition of the Encyclopedia of Chemical Technology is built on the solid foundation of the previous editions All of the articles have been rewritten and updated and many new subjects have been added to reflect changes in chemical technology through the 1970s The new edition, however, will be familiar to users of the earlier editions comprehensive, authoritative, accessible, lucid The Encyclopedia remains an indispensable information source for all producers and users of chemical products and materials In the Third Edition, emphasis is given to major present-day topics of concern to all chemists, scientists, and engineers--energy, health, safety, toxicology, and new materials New subjects have been added, especially those related to polymer and plastics technology, fuels and energy, inorganic and solid-state chemistry, composite materials, coating, fermentation and enzymes, pharmaceuticals, surfactant technology, fibers and textiles New features include the use of SI units as well as English units, Chemical Abstracts Service's Registry Numbers, and complete indexing based on automated retrieval from a machine-readable composition system Once again this classic serves as an unrivaled library of information for the chemical and allied industries Some comments about Kirk-Othmer-- The First Edition "No reference library worthy of the name will be without this series It is simply a must for the chemist and chemical engineer" --Chemical and Engineering News The Second Edition "A necessity for any technical library" --Choice
3,513 citations
TL;DR: Alanine levels were observed in all tissues indicative of a general inhibition of alanine transaminase activity and NMR spectral profiles of treated rats appeared similar to those of matched controls for all tissue types indicative of recovery from toxic insult.
Abstract: Hydrazine is a model toxin that induces both hepatotoxic and neurotoxic effects in experimental animals. The direct biochemical effects of hydrazine in kidney, liver, and brain tissue were assessed in male Sprague−Dawley rats using magic angle spinning nuclear magnetic resonance (NMR) spectroscopy. A single dose of hydrazine (90 mg/kg) resulted in changes to the biochemical composition of the liver after 24 h including an increase in triglycerides and β-alanine, together with a decrease in hepatic glycogen, glucose, choline, taurine, and trimethylamine-N-oxide (TMAO). From histopathology measurements of liver tissue, minimal to mild hepatocyte alteration was observed in all animals at 24 h. The NMR spectra of the renal cortex at 24 h after dosing were dominated by a marked increase in the tissue concentration of 2-aminoadipate (2-AA) and β-alanine, concomitant with depletions in TMAO, myo-inositol, choline, taurine, glutamate, and lysine. No alteration to the NMR spectral profile of the substantia nigra w...
432 citations
TL;DR: Using ZnO nanonails, a hydrazine electrochemical sensor has been fabricated, for the first time, which showed a high and reproducible sensitivity and the limit of detection (LOD) was estimated to be 0.2 microM.
424 citations
Journal Article•
TL;DR: A cross-sectional study evaluating the most common rocket fuels such as hydrazine; 1,1-dimethylhydrazine (UDMH); mono-methylhydrazines (MMH); and Aerozine-50 against the most commonly suggested therapies is needed to clarify the treatment implications for human exposure.
Abstract: Exposure to hydrazine and hydrazines' alkylated derivatives is an important occupational health issue, which will increase in significance as space applications increase. Despite their widespread usage as rocket fuels in manned and unmanned space and missile systems, serious exposures to hydrazines are rare. While a significant number of experimental studies were performed in the late 1950s through the mid-1960s, conflicting information exists concerning the most appropriate treatment for these exposures. A cross-sectional study evaluating the most common rocket fuels such as hydrazine; 1,1-dimethylhydrazine (UDMH); mono-methylhydrazine (MMH); and Aerozine-50 against the most commonly suggested therapies, such as pyridoxine, traditional antiseizure therapies, and arginine is needed to clarify the treatment implications for human exposure. Treatments that have been useful for hyperammonemic states, such as those for the six inherited urea cycle defects, have significant potential for the improvement of hydrazine exposure treatment.
229 citations
TL;DR: A ratiometric fluorescence probe that enables rapid, low-limit and naked-eye detection is successfully designed and used for hydrazine determination in live cells.
202 citations