A specific competitive inhibitor of angiotensin II.
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The compound was found to be a potent inhibitor of angiotensin II in vitro (isolated rat uterus strips) and in vivo (rat blood pressure) and did not inhibit the action of a number of other peptides and spasmogenic compounds.Abstract:
A peptide analog, [4-phenylalanine, 8-tyrosine]-angiotensin II, was prepared by solid phase peptide synthesis and its structure confirmed. The compound was found to be a potent inhibitor of angiotensin II in vitro (isolated rat uterus strips) and in vivo (rat blood pressure). The analog was found to be highly specific and did not inhibit the action of a number of other peptides and spasmogenic compounds.read more
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Journal Article
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
TL;DR: Although AT(1) receptors mediate most of the known actions of Ang II, the AT(2) receptor contributes to the regulation of blood pressure and renal function and the development of specific nonpeptide receptor antagonists has led to major advances in the physiology, pharmacology, and therapy of the renin-angiotensin system.
Book ChapterDOI
Solid-phase peptide synthesis.
TL;DR: It is a privilege to be able to contribute to this volume in which Professor Zervas’ friends, students, and colleagues have joined together to honor him and his remarkable contributions to peptide chemistry.
Journal ArticleDOI
Hypertension of renal origin: evidence for two different mechanisms
TL;DR: Data indicate that angiotensin II is in fact critically involved in the pathogenesis of the form of renal hypertension in which one renal artery is clamped and the contralateral kidney is left in place, but that it probably plays no significant role in the maintenance of experimental renal hypertension, in which the opposite kidney has been removed.
Journal ArticleDOI
Role of the Pressor Action of Angiotensin IIin Experimental Hypertension
TL;DR: The data indicate that, under certain experimental conditions, the blood pressure of rats during the acute phase of unilateral renal hypertension is maintained hy the endogenous angiotensin II, which was previously demonstrated to he present in the plasma in supernormal concentrations.
Journal ArticleDOI
Properties of angiotensin II receptors in the bovine and rat adrenal cortex.
TL;DR: The presence of high affinity specific binding sites for angiotensin II in bovine and rat adrenal cortex and suggest a plasma membrane location for the angiotENSin II receptors are illustrated.