Journal ArticleDOI
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.
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TLDR
Observations on the molecular basis of pleiotropic drug resistance are interpreted in terms of a model wherein certain surface glycoproteins control drug permeation by modulating the properties of hydrophobic membrane regions.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1976-11-11. It has received 3243 citations till now. The article focuses on the topics: Chinese hamster ovary cell & Glycoprotein.read more
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Multidrug resistance in cancer: role of ATP–dependent transporters
TL;DR: The ability to predict and circumvent drug resistance is likely to improve chemotherapy, and it has become apparent that resistance exists against every effective drug, even the authors' newest agents.
Journal ArticleDOI
Fish bioaccumulation and biomarkers in environmental risk assessment: a review
TL;DR: There is little doubt that measurements of bioaccumulation and biomarker responses in fish from contaminated sites offer great promises for providing information that can contribute to environmental monitoring programs designed for various aspects of ERA.
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Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
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Mechanisms of cancer drug resistance
TL;DR: The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance as mentioned in this paper.
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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
Alfred H. Schinkel,J. J. M. Smit,O. van Tellingen,Jos H. Beijnen,Els Wagenaar,L. Van Deemter,C. A. A. M. Mol,M. A. Van Der Valk,E. Robanus-Maandag,H te Riele,Anton Berns,Piet Borst +11 more
TL;DR: The findings explain some of the side effects in patients treated with a combination of carcinostatics and P-glycoprotein inhibitors and indicate that these inhibitors might be useful in selectively enhancing the access of a range of drugs to the brain.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
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Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.
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A Film Detection Method for Tritium‐Labelled Proteins and Nucleic Acids in Polyacrylamide Gels
TL;DR: A simple method for detecting 3H in polyacrylamide gels by scintillation autography (fluorography) using X-ray film, which is ten times more sensitive than conventional autoradiography of isotopes with higher emission energies.
Journal Article
Cellular Resistance to Actinomycin D in Chinese Hamster Cells in Vitro: Cross-Resistance, Radioautographic, and Cytogenetic Studies
June L. Biedler,Hansjörg Riehm +1 more
TL;DR: Investigations support the hypothesis that the development of resistance to AD in Chinese hamster cells is due to qualitative difference in cell membrane, resulting in decreased permeability to AD and other compounds.
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Reduced permeability in CHO cells as a mechanism of resistance to colchicine.
Victor Ling,Larry H. Thompson +1 more
TL;DR: The CHR lines were also cross resistant to other drugs such as actinomycin D, vinblastine and Colcemid; furthermore, the degree of cross resistance was positively correlated with thedegree of colchicine resistance.