A survey of Chinese herbal ingredients with liver protection activities
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TLDR
Seven different physicochemical parameters (MW, Clog P, CMR, μ, Ehomo, Elumo and Hf) and four major biological activities (antioxidant, anti-inflammatory, antiviral/antitumor and immunomodulating) are discussed in this review.Abstract:
A literature survey was conducted on herbs, their preparations and ingredients with reported liver protection activities, in which a total of 274 different species and hundreds of active ingredients have been examined. These ingredients can be roughly classified into two categories according to their activities: (1) the main ingredients, such as silybin, osthole, coumarin, glycyrrhizin, saikosaponin A, schisandrin A, flavonoids; and (2) supporting substances, such as sugars, amino acids, resins, tannins and volatile oil. Among them, some active ingredients have hepatoprotective activities (e.g. anti-inflammatory, anticancer, antioxidant, immunomodulating and liver cirrhosis-regulating effects). Calculation of physicochemical parameters indicates that the main ingredients with negative and positive Elumo values possibly display their hepatoprotective effects through different mechanisms, such as antioxidative, anti-inflammatory and immunomodulating effects. As the combination of herbs may achieve some treatment effects synergistically and/or additively, it is common in Chinese medicine to use mixtures of various medicinal herbs with pharmacologically active compounds to have synergistic and/or additive effects, or to reduce harmful effects of some pharmacologically active compounds. In particular, the active compounds with Clog P around 2 are suitable for passive transport across membranes and accessible to the target sites. Thus, Elumo and Clog P values are good indicators among the calculated parameters. Seven different physicochemical parameters (MW, Clog P, CMR, μ, Ehomo, Elumo and Hf) and four major biological activities (antioxidant, anti-inflammatory, antiviral/antitumor and immunomodulating) are discussed in this review. It is hoped that the discussion may provide some leads in the development of new hepatoprotective drugs.read more
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Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview.
TL;DR: The mechanism involved in drug-induced liver toxicity and the potential of herbal antioxidants as supplementary medication are discussed and the expanding prevalence and effectiveness of Ayurveda and natural products in the treatment of various disorders are looked into.
Journal ArticleDOI
Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.
TL;DR: The pharmacological properties of osthole are summarized and an overview of the underlying mechanisms are given, which showcase its potential as a multitarget alternative medicine.
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Saponins from Chinese Medicines as Anticancer Agents
Xiao-Huang Xu,Ting Li,Chi Man Vivienne Fong,Xiuping Chen,Xiaojia Chen,Yitao Wang,Mingqing Huang,Jin-Jian Lu +7 more
TL;DR: This review focuses on the anticancer properties of several typical naturally derived triterpenoids and saikosaponins and steroid saponins isolated from Chinese medicines.
Journal ArticleDOI
Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM).
TL;DR: Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, an ingredient of a Traditional Chinese Medicine, has received considerable attention recently because of its significant and diverse pharmacological activities, including anticancer, antisteoporotic, and antiproliferative, which make it a very promising natural lead compound for new drug discovery.
References
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The long term efficacy of glycyrrhizin in chronic hepatitis C patients
Yasuji Arase,Kenji Ikeda,Naoya Murashima,Kazuaki Chayama,Akihito Tsubota,Isao Koida,Yoshiyuki Suzuki,Satoshi Saitoh,Masahiro Kobayashi,Hiromitsu Kumada +9 more
TL;DR: Hepatocellular carcinoma occurs in patients with hepatitis C virus‐RNA positive chronic liver disease and it is important to prevent HCC with drug administration.
Journal Article
Silybum marianum (Carduus marianus)
P. Morazzoni,E. Bombardelli +1 more
TL;DR: This review deals with the botany, chemistry, pharmacology and the clinical efficacy of silymarin, sily bin and of a recently synthesized silybin derivative, Silipide.
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