Journal ArticleDOI
α-sympathetic receptor stimulation in the brain and hypotensive activity of α-methyldopa
A. Heise,G. Kroneberg +1 more
Reads0
Chats0
TLDR
It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.About:
This article is published in European Journal of Pharmacology.The article was published on 1972-02-01. It has received 84 citations till now. The article focuses on the topics: Yohimbine & Stimulation.read more
Citations
More filters
Journal ArticleDOI
A functional basis for classification of alpha-adrenergic receptors.
TL;DR: A division of adrenergic receptors into alpha and beta types could conceivably lead to the development of powerful agents even more selective for inhibition of renin release, control of blood pressure by a central site of action, reduction of fever, and possible other scientific or therapeutic applications.
Journal ArticleDOI
Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents.
S Z Langer,I Cavero,R Massingham +2 more
TL;DR: This report reviews a number of significant developments in the fields of noradrenergic transmission and adrenergic receptors which suggest that, in addition to the classical postsynaptic adrenoceptors, there are also presynaptic adrenOceptors that help modulate tbe release of norepinephrine from peripheral as well as central norADrenergic nerve endings during nerve stimulation.
Journal ArticleDOI
Neurophysiology and neuropharmacology of cardiovascular regulation and stress
TL;DR: The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
References
More filters
Journal ArticleDOI
Evidence for an α-sympathomimetic component in the effects of catapresan on vasomotor centres: Antagonism by piperoxane
TL;DR: Results support an α-adrenergic component in the inhibitory effect of catapresan on vasomotor centres and in dogs, decrease in blood pressure, heart rate and aortic blood flow induced by intracisternal injection of piperoxane was reduced or reversed.
Journal ArticleDOI
Norepinephrine metabolism in brainstem of spontaneously hypertensive rats.
TL;DR: Concentrations of norepinephrine in lower brainstem and hypothalamus of genetically hypertensive rats are significantly lower than in control rats and a possible relation of this central catecholamine deficiency to the hypertension is discussed.
Journal Article
Some biochemical effects of alpha-methyl-3,4-dihydroxyphenylalanine and related compounds in mice.
TL;DR: It is found that the ability of α-methyl-dopa to inhibit dopa decarboxylase and deplete tissues of norepinephrine resides solely in the L-isomer, and the effect was still discernible after 6 days.
Journal ArticleDOI
Central hypotensive effect of α-methyldopa
M. Henning,P. A. van Zwieten +1 more
TL;DR: In cats under chloralose anaesthesia l-α-methyldopa was infused for 1 hr into the left vertebral artery a gradual and significant lowering of mean arterial blood pressure was observed, and the dopamine and noradrenaline contents of the brain were significantly reduced while brain 5-hydroxytryptamine and heart nor adrenaline concentrations remained normal.
Journal ArticleDOI
α-Sympathicomimetische Eigenschaften als Ursache der blutdrucksteigernden und blutdrucksenkenden Wirkung von BAY 1470 (2-(2,6-Xylidino)-5,6-dihydro-4H-1,3-thiazinhydrochlorid)
TL;DR: The initial pressor response to BAY 1470 is followed by a prolonged fall in blood pressure; the latter seems to be due to an inhibition of the release of noradrenaline from the peripheral sympathetic neurones as well as to a central site of action.
Related Papers (5)
Evidence for an α-sympathomimetic component in the effects of catapresan on vasomotor centres: Antagonism by piperoxane
In‐Vivo Decarboxylation of α‐Methyl DOPA and α‐Methyl Metatyrosine
Arvid Carlsson,Margit Lindqvist +1 more