A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver
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Cites background from "A systematic review of follow-up bi..."
...Histologic inflammation and maybe metabolic factors are associated with higher risk of fibrosis progression among patients with simple steatosis or steatohepatitis [230]....
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References
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"A systematic review of follow-up bi..." refers background in this paper
...The present findings stress the need to revise current guidelines that do not recommend specific hepatic monitoring in NAFLD patients without NASH [2,19]....
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...Indeed, NAFLD encompasses both steatohepatitis (NASH), considered the more aggressive form of the disease, and NAFL (non-alcoholic fatty liver) grouping isolated steatosis and steatosis with mild lobular inflammation alone [1,2]....
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"A systematic review of follow-up bi..." refers background in this paper
...Later reports showed that patients with bland steatosis or steatosis and nonspecific inflammation have the same survival as the age- and sex-matched general population [14], while patients with steatohepatitis have increased liver-related mortality [15]....
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"A systematic review of follow-up bi..." refers result in this paper
...They were less insulin resistant as measured by surrogate markers and related clinical phenotypes, thus confirming observations made by others a decade ago [16]....
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