A systematic review of leukocyte telomere length and age in adults.
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Cites background from "A systematic review of leukocyte te..."
...The explanation of nearly 60% of variance of age is impressive compared with other so-called age biomarkers like telomere length where most studies show 15%–25% (42); thus, our new GlycanAge index appears to be more closely related to age than telomere lengths....
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Cites background from "A systematic review of leukocyte te..."
...Interestingly, decreased inflammation, but not telomere length (the shortening of which is often associated with chronological/biological aging [168]), is shown to be a predictor of healthy aging [169], which further supports the hypothesis that the IgG N-glycosylation changes, which are associated with inflammation, are a more suitable biomarker of biological age....
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"A systematic review of leukocyte te..." refers background in this paper
...This unstable state of chromosomes may lead to activation of molecular cascades involved in cellular stress responses, such as p53 and p16ink4a pathways, which may eventually result in apoptosis or cellular senescence (Harley et al., 1990; di Fagagna et al., 2003; Counter et al., 1992)....
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