scispace - formally typeset
Search or ask a question
Journal ArticleDOI

α-Tricalcium phosphate: Synthesis, properties and biomedical applications

01 Oct 2011-Acta Biomaterialia (Acta Biomater)-Vol. 7, Iss: 10, pp 3536-3546
TL;DR: It is as biocompatible as β-TCP, but more soluble, and hydrolyses rapidly to calcium-deficient hydroxyapatite, which makes α- TCP a useful component for preparing self-setting osteotransductive bone cements and biodegradable bioceramics and composites for bone repairing.
About: This article is published in Acta Biomaterialia.The article was published on 2011-10-01. It has received 479 citations till now.
Citations
More filters
Journal ArticleDOI
TL;DR: This feature article looks afresh at nano-HAp particles, highlighting the importance of size, crystal morphology control, and composites with other inorganic particles for biomedical material development.

1,215 citations

Journal ArticleDOI
TL;DR: This article is focused on nanosized HAp, although recent articles on microsized particles, especially those assembled from nanoparticles and/or nanocrystals, have been reviewed for comparison.

1,036 citations

Journal ArticleDOI
TL;DR: The aim of this manuscript is to highlight the tremendous improvements achieved in CaP materials research in the past 15 years, in particular in the field of biomineralization, as carrier for gene or ion delivery, as biologically active agent, and as bone graft substitute.

627 citations

Journal ArticleDOI
TL;DR: New insights on the contribution of material properties towards osteoinductivity and the role of signaling molecules involved in osteoblastic differentiation can potentially aid the design of CPC-based biomaterials that support bone regeneration without the need for additional biochemical supplements.

615 citations

Journal ArticleDOI
TL;DR: An overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties shows that, although the mechanical strength of CPC's is generally low, it is not a critical issue for their application for bone repair.

528 citations

References
More filters
Book
01 Jan 1994
TL;DR: In this paper, the authors describe the structure of carbonate apatites and the properties of apatite powders, including their properties in terms of their nucleation and crystal growth.
Abstract: 1. General Chemistry of the Calcium Orthophosphates. Introduction. Monocalcium phosphates (monohydrate and anhydrous). Octacalcium phosphate. Dicalcium phosphate dehydrate, brushite. Dicalcium phosphate anhydrous, monetite. Anhydrous tricalcium phosphates and whitlockite. Tetracalcium phosphate. Amorphous calcium phosphates. 2. Fluorapatite and chlorapatite. Introduction. Structures. Substitutions in apatites. Preparation of powders. Growth of single crystals. Infrared and Raman spectra. Other physical and chemical studies. 3. Hydroxapatite and Nonstoichiometric Apatites. Introduction. Structure of hydroxyapatite. Preparation of stoichiometric hydroxyapatite powders. Preparation of other apatites with hydroxyl ions. Growth of hydroxyapatite single crystals. Special analytical methods. Structure of calcium-deficient hydroxyapatites. Kinetics of nucleation and crystal growth. Solubility and interfacial phenomena. Reactions in solution. Infrared and Raman spectroscopy. NMR spectroscopy. Other physical and chemical studies. 4. Mineral, synthetic and biological carbonate apatites. Introduction. Francolite and dahllite. A-type carbonate apatite, Caio(PO4)6CO3. Synthetic high temperature B-type carbonate apatites. Carbonate apatites from aqueous systems. Biological apatites. Electron spin resonance of X-irradiated carbonate apatites. Summary. Appendix. Calculated X-ray diffraction patterns of the calcium orthophosphates. References. Index.

2,352 citations


"α-Tricalcium phosphate: Synthesis, ..." refers background in this paper

  • ...In contrast, b-TCP is stable at room temperature and transforms reconstructively [1,2] at 1125 C to a-TCP, which can be retained during cooling to room temperature [3]....

    [...]

Book
01 Jan 1984
TL;DR: In this paper, the authors present a detailed description of the properties of solid state chemistry, including point groups, space groups, and crystal structure, as well as some factors which influence crystal structure.
Abstract: What is Solid State Chemistry? Preparative Methods. Characterization of Inorganic Solids: Application of Physical Techniques. Thermal Analysis. X-ray Diffraction. Point Groups, Space Groups and Crystal Structure. Descriptive Crystal Chemistry. Some Factors Which Influence Crystal Structure. Crystal Defects and Non-Stoichiometry. Solid Solutions. Interpretation of Phase Diagrams. Phase Transitions. Ionic Conductivity and Solid Electrolytes. Electronic Properties and Band Theory: Metals, Semiconductors, Inorganic Solids, Colour. Other Electrical Properties. Magnetic Properties. Optical Properties: Luminescence, Lasers. Glass. Cement and Concrete. Refractories. Organic Solid State Chemistry. Appendixes. Index.

2,106 citations


"α-Tricalcium phosphate: Synthesis, ..." refers background in this paper

  • ...[99], so considerable energy has to be provided to the system to transform from one polymorph to another....

    [...]

Journal ArticleDOI
TL;DR: Calcium phosphates have a great biological and medical significance and in this review, an overview of the current knowledge in this subject is given.
Abstract: The inorganic part of hard tissues (bones and teeth) of mammals consists of calcium phosphate, mainly of apatitic structure. Similarly, most undesired calcifications (i.e. those appearing as a result of various diseases) of mammals also contain calcium phosphate. For example, atherosclerosis results in blood-vessel blockage caused by a solid composite of cholesterol with calcium phosphate. Dental caries result in a replacement of less soluble and hard apatite by more soluble and softer calcium hydrogenphosphates. Osteoporosis is a demineralization of bone. Therefore, from a chemical point of view, processes of normal (bone and teeth formation and growth) and pathological (atherosclerosis and dental calculus) calcifications are just an in vivo crystallization of calcium phosphate. Similarly, dental caries and osteoporosis can be considered to be in vivo dissolution of calcium phosphates. On the other hand, because of the chemical similarity with biological calcified tissues, all calcium phosphates are remarkably biocompatible. This property is widely used in medicine for biomaterials that are either entirely made of or coated with calcium phosphate. For example, self-setting bone cements made of calcium phosphates are helpful in bone repair and titanium substitutes covered with a surface layer of calcium phosphates are used for hip-joint endoprostheses and tooth substitutes, to facilitate the growth of bone and thereby raise the mechanical stability. Calcium phosphates have a great biological and medical significance and in this review we give an overview of the current knowledge in this subject.

1,819 citations

Book
01 Jan 1971
TL;DR: In this article, the authors define and define the definitions and theorems of group theory and symmetry groups, and present a mathematical model of symmetry groups for Inorganic and Organometallic Compounds.
Abstract: PRINCIPLES. Definitions and Theorems of Group Theory. Molecular Symmetry and the Symmetry Groups. Representations of Groups. Group Theory and Quantum Mechanics. Symmetry-Adapted Linear Combinations. APPLICATIONS. Molecular Orbital Theory and Its Applications in Organic Chemistry. Molecular Orbital Theory for Inorganic and Organometallic Compounds. Ligand Field Theory. Molecular Vibrations. Crystallographic Symmetry. Appendices. Index.

1,242 citations


"α-Tricalcium phosphate: Synthesis, ..." refers result in this paper

  • ...Theoretical calculations based on factor group symmetry [23] were carried out independently by two groups [22,24] and predicted more bands for space group P21 than were actually observed in both studies....

    [...]

Journal ArticleDOI
TL;DR: The main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds.
Abstract: Calcium phosphate (CaP) compounds are becoming of increasingly great importance in the field of biomaterials and, in particular, as bone substitutes. Recent discoveries have accelerated this process, but have simultaneously rendered the field more complicated for the everyday user. Subtle differences in composition and structure of CaP compounds may have a profound effect on their in vivo behaviour. Therefore, the main goal of this article is to provide a simple, but comprehensive presentation of CaP compounds. Reference is made to the most important commercial products.

885 citations


"α-Tricalcium phosphate: Synthesis, ..." refers background in this paper

  • ...However, empirical systems do not always fulfil thermodynamic predictions and other calcium phosphates, different from Hap, may be obtained as result of the dissolution of a-TCP [9,10]....

    [...]

  • ...and composites, and a-TCP is the major constituent of the powder component of various hydraulic bone cements [9,10]....

    [...]

  • ...Recent and excellent reviews have been already published on the subject [9,10,19,20,113]....

    [...]