A universal trend of amino acid gain and loss in protein evolution
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Cites background from "A universal trend of amino acid gai..."
...…that have shown the abundance of Cys in proteins has been increasing since divergence from the Last Universal Common Ancestor (Woese, 1998; Brooks and Fresco, 2002); and this increase is a continuing panspecies phenomenon which is evident within the last 10 million years (Jordan et al., 2005)....
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Cites methods from "A universal trend of amino acid gai..."
...To investigate the sequence dependence of the Θ-conditions, we chose four foldable proteins [cold shock protein, CspTm (3); cyclophilinA, hCyp (31); spectrin domains R15 and R17 (32)] and two more highly charged IDPs (prothymosin α, ProTα, and the N-terminal domain of HIV Integrase, IN) (4) (Fig....
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Cites background from "A universal trend of amino acid gai..."
...Although the prevalence of Cys in proteins is increasing, the abundance has not yet reached the neutral frequency (i.e., the frequency that would be expected based on the number of Cys codons in the genetic code) (King and Jukes, 1969; Brooks and Fresco, 2002)....
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