A very low power CMOS mixed-signal IC for implantable pacemaker applications
13 Sep 2004-Vol. 39, Iss: 12, pp 2446-2456
TL;DR: In this paper, a very low power interface IC used in implantable pacemaker systems is presented, which contains amplifiers, filters, ADCs, battery management system, voltage multipliers, high voltage pulse generators, programmable logic and timing control.
Abstract: Low power consumption is crucial for medical implant devices. A single-chip, very-low-power interface IC used in implantable pacemaker systems is presented. It contains amplifiers, filters, ADCs, battery management system, voltage multipliers, high voltage pulse generators, programmable logic and timing control. A few circuit techniques are proposed to achieve nanopower circuit operations within submicron CMOS process. Subthreshold transistor designs and switched-capacitor circuits are widely used. The 200 k transistor IC occupies 49 mm/sup 2/, is fabricated in a 0.5-/spl mu/m two-poly three-metal multi-V/sub t/ process, and consumes 8 /spl mu/W.
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TL;DR: Advanced materials and devices are reported that enable high-efficiency mechanical-to-electrical energy conversion from the natural contractile and relaxation motions of the heart, lung, and diaphragm, demonstrated in several different animal models, each of which has organs with sizes that approach human scales.
Abstract: Here, we report advanced materials and devices that enable high-efficiency mechanical-to-electrical energy conversion from the natural contractile and relaxation motions of the heart, lung, and diaphragm, demonstrated in several different animal models, each of which has organs with sizes that approach human scales. A cointegrated collection of such energy-harvesting elements with rectifiers and microbatteries provides an entire flexible system, capable of viable integration with the beating heart via medical sutures and operation with efficiencies of ∼2%. Additional experiments, computational models, and results in multilayer configurations capture the key behaviors, illuminate essential design aspects, and offer sufficient power outputs for operation of pacemakers, with or without battery assist.
752 citations
TL;DR: A comprehensive review of piezoelectric energy-harvesting techniques developed in the last decade is presented, identifying four promising applications: shoes, pacemakers, tire pressure monitoring systems, and bridge and building monitoring.
720 citations
TL;DR: This research shows a feasible approach to scavenge biomechanical energy, and presents a crucial step forward for lifetime-implantable self-powered medical devices.
Abstract: The first application of an implanted triboelectric nanogenerator (iTENG) that enables harvesting energy from in vivo mechanical movement in breathing to directly drive a pacemaker is reported. The energy harvested by iTENG from animal breathing is stored in a capacitor and successfully drives a pacemaker prototype to regulate the heart rate of a rat. This research shows a feasible approach to scavenge biomechanical energy, and presents a crucial step forward for lifetime-implantable self-powered medical devices.
450 citations
TL;DR: This review aims to highlight recent improvements in implantable triboelectric nanogenerators (iTENG) and implantable piezoelectrics nanogeners (iPENG) to drive self‐powered, wireless healthcare systems.
Abstract: Implantable medical devices (IMDs) have experienced a rapid progress in recent years to the advancement of state-of-the-art medical practices. However, the majority of this equipment requires external power sources like batteries to operate, which may restrict their application for in vivo situations. Furthermore, these external batteries of the IMDs need to be changed at times by surgical processes once expired, causing bodily and psychological annoyance to patients and rising healthcare financial burdens. Currently, harvesting biomechanical energy in vivo is considered as one of the most crucial energy-based technologies to ensure sustainable operation of implanted medical devices. This review aims to highlight recent improvements in implantable triboelectric nanogenerators (iTENG) and implantable piezoelectric nanogenerators (iPENG) to drive self-powered, wireless healthcare systems. Furthermore, their potential applications in cardiac monitoring, pacemaker energizing, nerve-cell stimulating, orthodontic treatment and real-time biomedical monitoring by scavenging the biomechanical power within the human body, such as heart beating, blood flowing, breathing, muscle stretching and continuous vibration of the lung are summarized and presented. Finally, a few crucial problems which significantly affect the output performance of iTENGs and iPENGs under in vivo environments are addressed.
441 citations
TL;DR: A wireless powering method is reported that overcomes the challenge of energy transfer beyond superficial depths in tissue by inducing spatially focused and adaptive electromagnetic energy transport via propagating modes in tissue and is used to power a tiny electrostimulator that is orders of magnitude smaller than conventional pacemakers.
Abstract: The ability to implant electronic systems in the human body has led to many medical advances. Progress in semiconductor technology paved the way for devices at the scale of a millimeter or less (“microimplants”), but the miniaturization of the power source remains challenging. Although wireless powering has been demonstrated, energy transfer beyond superficial depths in tissue has so far been limited by large coils (at least a centimeter in diameter) unsuitable for a microimplant. Here, we show that this limitation can be overcome by a method, termed midfield powering, to create a high-energy density region deep in tissue inside of which the power-harvesting structure can be made extremely small. Unlike conventional near-field (inductively coupled) coils, for which coupling is limited by exponential field decay, a patterned metal plate is used to induce spatially confined and adaptive energy transport through propagating modes in tissue. We use this method to power a microimplant (2 mm, 70 mg) capable of closed-chest wireless control of the heart that is orders of magnitude smaller than conventional pacemakers. With exposure levels below human safety thresholds, milliwatt levels of power can be transferred to a deep-tissue (>5 cm) microimplant for both complex electronic function and physiological stimulation. The approach developed here should enable new generations of implantable systems that can be integrated into the body at minimal cost and risk.
430 citations
Cites background from "A very low power CMOS mixed-signal ..."
...4-μJ pulses at rates dependent on the extracted power; its characteristic dimension is at least an order of magnitude smaller than existing commercial pacemakers (29) due to the absence of a battery (Fig....
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...These levels are far greater than requirements for advanced integrated circuits (Table S1); in comparison, cardiac pacemakers consume ∼8 μW (1, 29)....
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References
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Patent•
15 Oct 1996
TL;DR: In this paper, an improved apparatus and method for providing a measurement of the charge depleted from a battery used in an implantable device such as a cardiac pacemaker is described, which is provided not by measuring the voltage level or impedance of the battery, but rather by continuously measuring the electrical current drawn from the battery and integrating that measured current over an integration time period.
Abstract: An improved apparatus and method are described for providing a measurement of the charge depleted from a battery used in an implantable device such as a cardiac pacemaker. The measurement is provided not by measuring the voltage level or impedance of the battery, but rather by continuously measuring the electrical current drawn from the battery and integrating that measured current over an integration time period. A precision current-sensing resistor provides a sense signal having a voltage that varies according to the magnitude of current being drawn, and this sense signal is integrated using a voltage-controlled oscillator circuit and counter, which are implemented using CMOS circuitry arranged in a switched-capacitor topology.
68 citations
15 May 1989
TL;DR: In this article, a system of four integrated circuits along with discretes that form part of an implantable defibrillator is described, along with a 12-bit integrating analog-to-digital converter that monitors several system utility voltages including battery terminal voltage.
Abstract: A system of four integrated circuits along with discretes that form part of an implantable defibrillator is outlined. Circuit techniques to reduce battery power drain and a 12-bit integrating analog-to-digital converter that monitors several system utility voltages including battery terminal voltage, are presented. Typical system current drain is 20 mA
29 citations
16 May 1988
TL;DR: A description is presented of a single-chip, microcomputer-based pacemaker system in which high-level analog functions are integrated on the same IC as a 8-bit microcomputer and a DC-DC converter.
Abstract: A description is presented of a single-chip, microcomputer-based pacemaker system in which high-level analog functions are integrated on the same IC as a 8-bit microcomputer and a DC-DC converter. Low voltage and low current techniques are used, as well as circuitry to compensate for any long-term drift of transistor characteristics. Each functional block is programmable and can therefore be used in a variety of other implantable, biomedical applications. >
9 citations