α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice.
Fengfei Ding,John O’Donnell,Alexander S. Thrane,Douglas Zeppenfeld,Hongyi Kang,Lulu Xie,Fushun Wang +6 more
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TLDR
It is shown that the synchronized release of norepinephrine from locus coeruleus projections throughout the cerebral cortex mediate long-ranging Ca2+ signals by activation of astrocytic α1-adrenergic receptors, which may coordinate the broad effects of neuromodulators on neuronal activity.About:
This article is published in Cell Calcium.The article was published on 2013-12-01 and is currently open access. It has received 325 citations till now. The article focuses on the topics: Stimulation & Cerebral cortex.read more
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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse.
Ye Zhang,Steven A. Sloan,Laura E. Clarke,Christine Caneda,Colton A. Plaza,Paul D. Blumenthal,Hannes Vogel,Gary K. Steinberg,Michael S. B. Edwards,Gordon Li,John A. Duncan,Samuel H. Cheshier,Lawrence M. Shuer,Edward F. Chang,Gerald A. Grant,Melanie Hayden Gephart,Ben A. Barres +16 more
TL;DR: The development of an immunopanning method to acutely purify astrocytes from fetal, juvenile, and adult human brains and to maintain these cells in serum-free cultures is reported, finding that human astroCytes have abilities similar to those of murine astroicytes in promoting neuronal survival, inducing functional synapse formation, and engulfing synaptosomes.
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Physiology of astroglia
TL;DR: Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
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Diversity of astrocyte functions and phenotypes in neural circuits
TL;DR: New insights herald the concept that astrocytes represent a diverse population of genetically tractable cells that mediate neural circuit–specific roles in health and disease.
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Astrocyte Calcium Signaling: The Third Wave
Narges Bazargani,David Attwell +1 more
TL;DR: The discovery that transient elevations of calcium concentration occur in astrocytes, and release 'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea that astroCytes are powerful regulators of neuronal spiking, synaptic plasticity and brain blood flow.
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Cell Biology of Astrocyte-Synapse Interactions
Nicola J. Allen,Cagla Eroglu +1 more
TL;DR: This review summarizes some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication and poses some pressing questions that need to be addressed to advance mechanistic understanding of the role ofAstrocytes in regulating synaptic development.
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An Integrative Theory of Locus Coeruleus-Norepinephrine Function: Adaptive Gain and Optimal Performance.
TL;DR: In this article, the locus coeruleus-norepinephrine (LC-NE) system plays a more complex and specific role in the control of behavior than investigators previously thought.
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Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile Mice
TL;DR: A technique for two-photon fluorescence imaging with cellular resolution in awake, behaving mice with minimal motion artifact is reported, demonstrating that running-associated brain motion is limited to approximately 2-5 microm.
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Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
Gary Aston-Jones,Floyd E. Bloom +1 more
TL;DR: It is proposed that pronouced NE-LC discharge may enhance activity within target cell systems primarily concerned with processing salient external stimuli and suppress cental nervous system activity related more to tonic, vegetative functions, which may bias global behavioral orientation between stimuli in the external versus internal environments.
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Glial Calcium: Homeostasis and Signaling Function
TL;DR: By controlling gap junction conductance, Ca2+ waves may define the limits of functional glial networks, and there is some evidence that glial [Ca2+]i waves can affect neurons.
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Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.
Xiaohai Wang,Nanhong Lou,Qiwu Xu,Guo-Feng Tian,Weiguo Peng,Xiaoning Han,Jian Kang,Takahiro Takano +7 more
TL;DR: It is shown that whisker stimulation evokes increases in astrocytic cytosolic calcium (Ca2+) within the barrel cortex of adult mice, and that increases in Astrocytic Ca2+ occur independently of postsynaptic excitatory activity.