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AASLD 2016 Recommendations for Testing, Managing, and Treating Hepatitis C
Rasha Kamel
- Vol. 4, Iss: 4, pp 24-27
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The article was published on 2017-05-01. It has received 442 citations till now. The article focuses on the topics: Hepatitis C.read more
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Review of recent research on hepatitis C therapy for 54th annual meeting of the American association for the study of liver diseases
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EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis.
TL;DR: Liver biopsy gives a snapshot and not an insight into the dynamic changes during the process of fibrogenesis, so immunohistochemical evaluation of cellular markers such as smooth muscle actin expression for hepatic stellate cell activation, cytokeratin 7 for labeling ductular proliferation or CD34 for visualization of sinusoidal endothelial capillarization can provide additional ‘‘functional’’ information.
Journal ArticleDOI
The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation
Josh Levitsky,Richard N. Formica,Roy D. Bloom,Michael Charlton,Michael P. Curry,John J. Friedewald,Joelle Y. Friedman,David S. Goldberg,Shelley A. Hall,Michael G. Ison,Tiffany E. Kaiser,David K. Klassen,G Klintmalm,Jon A. Kobashigawa,AnnMarie Liapakis,K. O'Conner,Peter P. Reese,Darren Stewart,Norah A. Terrault,Nicole Theodoropoulos,James F. Trotter,Elizabeth C. Verna,Michael L. Volk +22 more
TL;DR: An urgent need exists for prospective research protocols that study the risk versus benefit of using organs for hepatitis C–infected donors, because these organs are frequently discarded and typically come from younger donors, and have the potential to save lives on the solid organ transplant waitlist.
Journal ArticleDOI
Hepatitis C virus drug resistance–associated substitutions: State of the art summary
Erik Lontok,Patrick R. Harrington,Anita Y. M. Howe,Tara L. Kieffer,Johan Lennerstrand,Oliver Lenz,Fiona McPhee,Hongmei Mo,Neil Parkin,Tami Pilot-Matias,Veronica Miller +10 more
TL;DR: The viral proteins targeted by HCV direct‐acting antivirals are discussed and clinically relevant resistance data for compounds that have been approved or are currently in phase 3 clinical trials are summarized.
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Safety and efficacy of sofosbuvir‐containing regimens in hepatitis C‐infected patients with impaired renal function
Varun Saxena,Farrukh M. Koraishy,Meghan E. Sise,Joseph K. Lim,Monica Schmidt,Raymond T. Chung,AnnMarie Liapakis,David R. Nelson,Michael W. Fried,Norah A. Terrault,Hcv-Target +10 more
TL;DR: This work assessed the safety and efficacy of SOF‐containing regimens in patients with varying baseline estimated glomerular filtration rate (eGFR) and concluded that these regimens should be considered as safe and effectiveixtures.
References
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2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Neil J. Stone,Jennifer G. Robinson,Alice H. Lichtenstein,C. Noel Bairey Merz,Conrad B. Blum,Robert H. Eckel,Anne C. Goldberg,David Lee Gordon,Daniel Levy,Donald M. Lloyd-Jones,Patrick E. McBride,J. Sanford Schwartz,Susan T. Shero,Sidney C. Smith,Karol E. Watson,Peter W.F. Wilson +15 more
TL;DR: Preamble and Transition to ACC/AHA Guidelines to Reduce Cardiovascular Risk S2 The goals of the …
Journal ArticleDOI
A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
Chun-Tao Wai,Joel K. Greenson,Robert J. Fontana,John D. Kalbfleisch,Jorge A. Marrero,Hari S. Conjeevaram,Anna S.F. Lok +6 more
TL;DR: It is shown that a simple index using readily available laboratory results can identify CHC patients with significant fibrosis and cirrhosis with a high degree of accuracy and may decrease the need for staging liver biopsy specimens among patients with CHC.
Journal ArticleDOI
Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
Richard K. Sterling,Eduardo Lissen,Eduardo Lissen,Nathan Clumeck,Ricard Solà,Mendes Cassia Correa,Julio S. G. Montaner,Mark S. Sulkowski,Francesca J. Torriani,Doug T. Dieterich,David L. Thomas,Diethelm Messinger,Mark T. Nelson +12 more
TL;DR: In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV‐coinfected patients.
Journal ArticleDOI
Diagnosis, management, and treatment of hepatitis C: An update
TL;DR: This document has been approved by the AASLD, the Infectious Diseases Society of America, and the American College of Gastroenterology.
Journal ArticleDOI
Natural history of liver fibrosis progression in patients with chronic hepatitis C
TL;DR: The host factors of ageing, alcohol consumption, and male sex have a stronger association with fibrosis progression than virological factors in HCV infection.
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