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Ability of King's College Criteria and Model for End-Stage Liver Disease Scores to Predict Mortality of Patients With Acute Liver Failure: A Meta-analysis

Mark J. W. McPhail, +5 more
- 01 Apr 2016 - 
- Vol. 14, Iss: 4, pp 516-525
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TLDR
Based on a meta-analysis of studies, the KCC more accurately predicts hospital mortality among patients with AALF, whereas MELD scores more accurately predict mortalityamong patients with NAALF.
About: 
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2016-04-01 and is currently open access. It has received 91 citations till now. The article focuses on the topics: King's College Criteria & Model for End-Stage Liver Disease.

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ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

Naga Chalasani, +5 more
- 01 Jul 2014 - 
TL;DR: This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.
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EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.

Julia Wendon, +9 more
- 01 May 2017 - 
TL;DR: The term acute liver failure (ALF) is frequently applied as a generic expression to describe patients presenting with or developing an acute episode of liver dysfunction, however, it refers to a highly specific and rare syndrome, characterised by an acute abnormality of liver blood tests in an individual without underlying chronic liver disease.
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Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and Acute Liver Failure

Chalermrat Bunchorntavakul, +1 more
- 01 May 2018 - 
TL;DR: N-acetylcysteine is recommended for all patients with APAP-induced ALF and it reduces mortality and Liver transplantation should be offered early to those who are unlikely to survive based on described prognostic criteria.
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Prognostic modeling in pediatric acute liver failure.

Vandana Jain, +1 more
- 01 Oct 2016 - 
TL;DR: The challenges with prognostic modeling in PALF are discussed and predictive methods that are currently available and in development for the future are described.
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Acute liver failure: An up-to-date approach.

Filipe S. Cardoso, +3 more
- 01 Jun 2017 - 
TL;DR: The current diagnostic and therapeutic approach to acute liver failure is reviewed, especially in the intensive care unit setting, to improve patients' outcomes and selection of patients for liver transplantation.
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Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes See Editorial on Page 1397 Potential conflict of interest: Nothing to report. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

Ryan M. Taylor, +8 more
Journal ArticleDOI

Meta-analysis of performance of Kings’s College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure

Mark J. W. McPhail, +2 more
- 01 Sep 2010 - 
TL;DR: KCC for outcome in non-POD ALF have good specificity and more limited sensitivity and in historically earlier studies suggesting modern medical management of ALF may modify performance of KCC, there is significant heterogeneity in the published data partially related to methodological quality.
Journal ArticleDOI

Etiologies and outcomes of acute liver failure in Germany.

Johannes Hadem, +13 more
- 01 Jun 2012 - 
TL;DR: In Germany, drug toxicity, indeterminate etiology, and viral hepatitis appear to be the major causes of primary ALF, which has high mortality and is at great risk of progressing to multiple organ failure.
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MELD score to predict outcome in adult patients with non‐acetaminophen‐induced acute liver failure

Aezam Katoonizadeh, +10 more
- 01 Apr 2007 - 
TL;DR: The prognostic value of MELD score was analyzed in patients with ALF who were prospectively registered in the database since 1990 and found to be an excellent predictor of mortality.
Journal ArticleDOI

Intensive care management of acute liver failure.

William Bernal, +3 more
- 01 May 2008 - 
TL;DR: Practical clinical approaches to the care of critically ill patients with ALF are discussed, taking an organ systems-based perspective and discussing the underlying pathophysiological processes and major areas of uncertainty as to what constitutes best practice.
Related Papers (5)

Early indicators of prognosis in fulminant hepatic failure

John O'Grady, +3 more
- 01 Aug 1989 - 

Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States

George Ostapowicz, +32 more
- 17 Dec 2002 - 

Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure

William M. Lee, +10 more
- 01 Sep 2009 - 

EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.

Julia Wendon, +9 more
- 01 May 2017 - 

Acute liver failure: redefining the syndromes

John O'Grady, +2 more
- 31 Jul 1993 - 
Frequently Asked Questions (2)
Q1. What have the authors contributed in "Meta-analysis of king's college criteria and model for end stage liver disease to predict outcome in acute liver failure" ?

The authors assessed the accuracy of King 's College Criteria ( KCC ) versus the Model-forEnd-Stage-Liver-Disease ( MELD ) in ALF through meta-analysis of studies which report the accuracy of both tests. 

The authors hope these data help inform such decisions and future research. A worsening grade of HE can be detected at the bedside and incorporated into KCC without awaiting further biochemical analysis.