Journal ArticleDOI
Abnormal intestinal permeability in children with autism.
Patrizia D'Eufemia,Mauro Celli,R. Finocchiaro,Lucia Pacifico,L Viozzi,M. Zaccagnini,Ettore Cardi,Omero Giardini +7 more
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TLDR
It is speculated that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities.Abstract:
We determined the occurrence of gut mucosal damage using the intestinal permeability test in 21 autistic children who had no clinical and laboratory findings consistent with known intestinal disorders. An altered intestinal permeability was found in 9 of the 21 (43%) autistic patients, but in none of the 40 controls. Compared to the controls, these nine patients showed a similar mean mannitol recovery, but a significantly higher mean lactulose recovery (1.64% +/- 1.43 vs 0.38% +/- 0.14; P < 0.001). We speculate that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormalities.read more
Citations
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Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Elaine Y. Hsiao,Sara Mcbride,Sophia Hsien,Gil Sharon,Embriette R. Hyde,Tyler McCue,Julian A. Codelli,Janet Chow,Sarah E. Reisman,Joseph F. Petrosino,Paul H. Patterson,Sarkis K. Mazmanian +11 more
TL;DR: A gut-microbiome-brain connection in a mouse model of ASD is supported and a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders is identified.
Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TL;DR: In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.
Journal ArticleDOI
The screening and diagnosis of autistic spectrum disorders
Pauline A. Filipek,Pasquale J. Accardo,Grace T. Baranek,Edwin H. Cook,Geraldine Dawson,Barry Gordon,Judith S. Gravel,Chris Plauché Johnson,Ronald J. Kallen,Susan E. Levy,Nancy J. Minshew,Barry M. Prizant,Isabelle Rapin,Sally J. Rogers,Wendy L. Stone,Stuart W. Teplin,Roberto Tuchman,Fred R. Volkmar +17 more
TL;DR: Specific detailed recommendations for each level have been established in this document, which are intended to improve the rate of early suspicion and diagnosis of, and therefore early intervention for, autism.
Journal ArticleDOI
Gastrointestinal Microflora Studies in Late-Onset Autism
Sydney M. Finegold,Sydney M. Finegold,Denise Molitoris,Yuli Song,Chengxu Liu,Marja Liisa Vaisanen,Ellen R. Bolte,Maureen McTeague,Richard H. Sandler,Hannah M. Wexler,Hannah M. Wexler,Elizabeth M. Marlowe,Elizabeth M. Marlowe,Matthew D. Collins,Paul A. Lawson,Paula Summanen,Mehmet Baysallar,Thomas J. Tomzynski,Erik K. Read,Eric A. Johnson,Rial D. Rolfe,Palwasha Nasir,Haroun N. Shah,David A. Haake,David A. Haake,Patricia Manning,Ajay Kaul +26 more
TL;DR: Significant alterations in the upper and lower intestinal flora of children with late-onset autism are demonstrated and may provide insights into the nature of this disorder.
Journal ArticleDOI
Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
TL;DR: The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.
References
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Aspects of Autism: Biological Research: edited by Lorna Wing, The National Autistic Society, 1988. £7.50 (120 pages) ISBN 0 902241 25 7
TL;DR: In this paper, a collection of ten talks given at a conference on autism held at the University of Kent, UK is presented, covering clinical, anecdotal and psychological clues to the underlying disorder, possible genetic and viral etiologies, biochemical correlates and attempted drug treatments.
Journal ArticleDOI
Childhood psychosis and urinary excretion of peptides and protein-associated peptide complexes.
TL;DR: It is argued that these products that give ultraviolet absorbancy peaks of the chromatograms possibly correspond to peptides and protein-associated peptide complexes and are probably at least partly of CNS origin.
Journal Article
Autism: current understanding and management.
TL;DR: This review considers the current understanding of genetic factors and associated medical conditions, together with a discussion of some aspects of management and treatment of affected children and adolescents.
Journal Article
Choosing a management course for doctors.
TL;DR: Doctors should be aware of the range and availability of 'management training course' opportunities which will complement their clinical practice and support their greater involvement in the wider management role.
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