Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study
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...…as molecular marker of artemisinin resistance (C580Y, R539T, I543T, Y493H), confirming previous smaller-sized studies (Conrad et al. 2014; Torrentino-Madamet et al. 2014; Cooper et al. 2015; Escobar et al. 2015; Hawkes et al. 2015; Isozumi et al. 2015; Kamau et al. 2015; Taylor et al. 2015)....
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...It is thought that artemisinin resistance has not been established in Africa, supported by the additional absence of evidence of invasion by Asian K13 alleles validated as molecular marker of artemisinin resistance (C580Y, R539T, I543T, Y493H), confirming previous smaller-sized studies (Conrad et al. 2014; Torrentino-Madamet et al. 2014; Cooper et al. 2015; Escobar et al. 2015; Hawkes et al. 2015; Isozumi et al. 2015; Kamau et al. 2015; Taylor et al. 2015)....
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...Thus there is considerable uncertainty about the epidemiological significance of the growing number of non-synonymous KPBD mutations reported in Africa (Ashley et al., 2014; Hopkins Sibley, 2015; Kamau et al., 2015; Taylor et al., 2015)....
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...Previous studies in Africa have not identified variants known to cause resistance in Southeast Asia (Kamau et al., 2015; Taylor et al., 2015)....
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