Journal ArticleDOI
Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.
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TLDR
The mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercETin-3-glucOSide appears to be absorbed only following hydrolytic action of LPH.About:
This article is published in Biochemical Pharmacology.The article was published on 2003-04-01. It has received 295 citations till now. The article focuses on the topics: Phlorizin & Glucoside.read more
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Polyphenols: food sources and bioavailability
TL;DR: The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
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Apple phytochemicals and their health benefits
Jeanelle Boyer,Rui Hai Liu +1 more
TL;DR: The purpose of this paper is to review the most recent literature regarding the health benefits of apples and their phytochemistryicals, phytochemical bioavailability and antioxidant behavior, and the effects of variety, ripening, storage and processing on apple phytochemicals.
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Anthocyanins: Natural Colorants with Health-Promoting Properties
Jian He,M. Monica Giusti +1 more
TL;DR: The bioactivity of bioavailable anthocyanins should be a focus of future research regarding their putative health-promoting effects.
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Citrus Flavonoids: molecular structure, biological activity and nutritional properties: a review
TL;DR: The present review summarizes the existing bibliography on biological and pharmacological studies of Citrus flavonoids, both in vitro and in vivo, and suggests that dietary flavonoid intakes may help to supplement the body antioxidant defences against free radicals.
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Quercetin: A flavonol with multifaceted therapeutic applications?
TL;DR: In this review the molecular, cellular, and functional bases of therapy will be emphasized taking strictly into account data appearing in the peer-reviewed literature and summarizing the main therapeutic applications of quercetin, the drug metabolism and the main drug interaction as well as the potential toxicity will be also spotlighted.
References
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Journal ArticleDOI
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
Andrea J. Day,F. Javier Cañada,Juan C Dı́az,Paul A. Kroon,Russell Mclauchlan,Craig B. Faulds,Geoff W. Plumb,Michael R. A. Morgan,Gary Williamson +8 more
TL;DR: The ability of LPH to deglycosylate dietary (iso)flavonoid glycosides suggests a possible role for this enzyme in the metabolism of these biologically active compounds.
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Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver β-glucosidase activity
Andrea J. Day,M.Susan DuPont,Saxon Ridley,M. J. C. Rhodes,Michael J. C. Rhodes,Michael R. A. Morgan,Gary Williamson +6 more
TL;DR: The enzymatic activity of the cell‐free extracts exhibits similar properties to the cytosolic broad‐specificity β‐glucosidase previously described in mammals.
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Pharmacokinetics and bioavailability of quercetin glycosides in humans.
Eva Ulrike Graefe,Joerg Wittig,Silke C. Mueller,Anne-Kathrin Riethling,Bernhard Uehleke,Bernd Drewelow,Holger Pforte,Gisela Jacobasch,Hartmut Derendorf,Markus Veit +9 more
TL;DR: The disposition of quercetin in humans primarily depends on the sugar moiety, and to a minor extent, the plant matrix influences both the rate and extent of absorption in the case of buckwheat tea administration compared with the isolated compound.
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Flavonols and flavones in food plants: a review†
TL;DR: The qualitative and quantitative occurrence of flavonols and flavones, particularly in fruit and vegetables, are considered in this paper, where the authors present a review of the qualitative, quantitative and qualitative occurrence of these compounds.
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The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
Peter C. H. Hollman,M.N.C.P. Bijsman,Y. van Gameren,E.P.J. Cnossen,J. de Vries,Martijn B. Katan +5 more
TL;DR: It is suggested that quercetin glucoside is actively absorbed from the small intestine, whereas quercettin rutinoside is absorbed fromThe colon after deglycosylation, suggesting that Absorption of other food components might also be enhanced by attachment of a glucose group.