Access to the Nucleus and Functional Association with c-Myc Is Required for the Full Oncogenic Potential of ΔEGFR/EGFRvIII
Citations
179 citations
Cites background from "Access to the Nucleus and Functiona..."
...Similar genetic derangements have been reported in human gliomas [67-69]....
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53 citations
Cites background from "Access to the Nucleus and Functiona..."
...5AandB); this suggests that the rate of nEGFRexport, via its nuclear export sequence (28), varies between cell lines....
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...These nuclear functions have been linked to three parameters of tumor biology: (i) inverse correlation with overall survival innumerous cancers (15–20), (ii) resistance to therapeutic agents including radiation (12, 21–24), chemotherapy (12, 13, 24), and anti-EGFR therapies gefitinib (25) and cetuximab (26), and (iii) enhanced tumor growth (27, 28)....
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42 citations
Cites background from "Access to the Nucleus and Functiona..."
...In 2013, Bogler and colleagues performed a ChIP-Seq in conjunction with bioinformatics analysis to identify genomewide targets of EGFRvIII and demonstrated that nuclear EGFRvIII associates with c-Myc on E-box-containing promoters, driving oncogenic functions in glioblastoma cells [40]....
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...[40] Gururaj AE, Gibson L, Panchabhai S, Bai M, Manyam G, Lu Y, Latha K, Rojas ML, Hwang Y, Liang S and Bogler O....
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39 citations
39 citations
References
13,008 citations
"Access to the Nucleus and Functiona..." refers methods in this paper
...ChIP-enriched binding peaks were identified by Model-based analysis of ChIP-Seq (MACS) (26)....
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3,730 citations
2,203 citations
"Access to the Nucleus and Functiona..." refers background in this paper
...Expression of EGFR (also called EGFRvIII), the most common mutation of EGFR (1), correlates with advanced disease and resistance to therapy (2)....
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1,194 citations
1,142 citations
"Access to the Nucleus and Functiona..." refers background in this paper
...c-Myc is known to bind to the E-box motifs enriched in our dataset (17) and has been implicated in gliomagenesis (38)....
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...We identified that the E-box motif, which is the binding motif of the c-Myc/Max obligatory heterodimer (17), is enriched in EGFR targeted promoters....
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