Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior
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TLDR
Action of cholinergic signaling on cellular and synaptic properties of neurons in several brain areas are identified and consequences of this signaling on behaviors related to drug abuse, attention, food intake, and affect are discussed.About:
This article is published in Neuron.The article was published on 2012-10-04 and is currently open access. It has received 912 citations till now. The article focuses on the topics: Cholinergic & Acetylcholine.read more
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Graphene-based materials for tissue engineering.
Su Ryon Shin,Su Ryon Shin,Yi-Chen Li,Hae Lin Jang,Parastoo Khoshakhlagh,Mohsen Akbari,Amir Nasajpour,Yu Shrike Zhang,Ali Tamayol,Ali Khademhosseini +9 more
TL;DR: Graphene and its chemical derivatives have been a pivotal new class of nanomaterials and a model system for quantum behavior and the opportunities in the usage of graphene-based materials for clinical applications are outlined.
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Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline
TL;DR: This Review attempts to identify areas of controversy, as well as consensus, on what is and is not yet known about how cholinergic signaling in the CNS contributes to normal cognitive processes, and delineates the findings from recent work on the extent to which Dysfunction of Cholinergic circuits contributes to cognitive decline associated with neurodegenerative disorders.
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Neural regulation of immunity: molecular mechanisms and clinical translation
TL;DR: Findings from recent clinical studies of bioelectronic neuromodulation in inflammatory and autoimmune diseases are summarized and mechanistic insights are outlined focusing on translational relevance and conceptual developments.
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Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior.
Yann S. Mineur,Adetokunbo Obayemi,Mattis B. Wigestrand,Gianna M. Fote,Cali A. Calarco,Alice M. Li,Marina R. Picciotto +6 more
TL;DR: It is demonstrated that ACh signaling in the hippocampus promotes behaviors related to anxiety and depression, and abnormalities in the cholinergic system may be critical for the etiology of mood disorders and could represent an endophenotype of depression.
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A cellular and regulatory map of the cholinergic nervous system of C. elegans
Laura Pereira,Laura Pereira,Paschalis Kratsios,Paschalis Kratsios,Esther Serrano-Saiz,Esther Serrano-Saiz,Hila Sheftel,Avi Mayo,David H. Hall,John G. White,Brigitte LeBoeuf,L. Rene Garcia,L. Rene Garcia,Uri Alon,Oliver Hobert,Oliver Hobert +15 more
TL;DR: It is found that acetylcholine (ACh) is the most broadly used neurotransmitter and its usage relative to other neurotransmitters within the context of the entire connectome and within specific network motifs embedded in the connectome.
References
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The amygdala modulates the consolidation of memories of emotionally arousing experiences
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Uncertainty, neuromodulation, and attention.
Angela J. Yu,Peter Dayan +1 more
TL;DR: This formulation is consistent with a wealth of physiological, pharmacological, and behavioral data implicating acetylcholine and norepinephrine in specific aspects of a range of cognitive processes and suggests a class of attentional cueing tasks that involve both neuromodulators and how their interactions may be part-antagonistic, part-synergistic.