Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models
Citations
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Cites methods from "Acinetobacter baumannii: Human infe..."
...genus’ putative virulence factors (60, 93)....
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...baumannii infection, artificial models have been used, such as infecting mice intraperitoneally (a clinically irrelevant route of entry) or mixing the inoculum with porcine mucin as a foreign body that inhibits the host’s immune system from rapidly clearing the organism (59, 60)....
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572 citations
Cites background or result from "Acinetobacter baumannii: Human infe..."
...baumannii, compared to those in other Gram-negative pathogens (McConnell et al., 2013)....
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...In A. baumannii, OmpA is the very well-characterized virulence factor with a variety of interesting biological properties identified in in vitro model systems (Smith et al., 2007; McConnell et al., 2013)....
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...Although recent genomic and phenotypic analyses of A. baumannii have identified several virulence factors responsible for its pathogenicity, relatively few virulence factors have been identified in A. baumannii, compared to those in other Gram-negative pathogens (McConnell et al., 2013)....
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...Many reports have shown that A. baumannii rapidly develops resistance to antimicrobials, and multidrug-resistant strains have been isolated (McConnell et al., 2013)....
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...baumannii, OmpA is the very well-characterized virulence factor with a variety of interesting biological properties identified in in vitro model systems (Smith et al., 2007; McConnell et al., 2013)....
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240 citations
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References
11,162 citations
"Acinetobacter baumannii: Human infe..." refers background in this paper
...baumannii to biotic and abiotic surfaces results in the development of biofilms, which are complex multicellular three-dimensional structures with cells in intimate contact with each other and encased in an extra-cellular matrix that can be comprised of carbohydrates, nucleic acids, proteins, and other macromolecules (Costerton et al., 1999)....
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...…in the development of biofilms, which are complex multicellular three-dimensional structures with cells in intimate contact with each other and encased in an extra-cellular matrix that can be comprised of carbohydrates, nucleic acids, proteins, and other macromolecules (Costerton et al., 1999)....
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5,748 citations
4,084 citations
"Acinetobacter baumannii: Human infe..." refers background in this paper
...Acinetobacter baumannii is also a common cause of bloodstream infections in the intensive care setting (Wisplinghoff et al., 2004)....
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...Crude mortality rates for A. baumannii bloodstream infections have been reported to be between 28% and 43% (Seifert et al., 1995; Wisplinghoff et al., 2004)....
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...While these studies provide important information regarding the epidemiology and clinical management of A. baumannii infections, they do not address the underlying biological basis for the increasing success of this organism as a human pathogen....
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2,915 citations
"Acinetobacter baumannii: Human infe..." refers background or result in this paper
...A subsequent study demonstrated that A. baumannii reduced the ability of C. albicans to kill C. elegans during co-infection, demonstrating that this model can be used to study eukaryote–prokaryote interactions (Peleg et al., 2008b)....
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...…heme, a host product that could be available to bacteria at sites where extensive cell and tissue damage are produced by infections such as necrotizing fasciitis (Brachelente et al., 2007; Charnot-Katsikas et al., 2009; Corradino et al., 2010) or in severely injured patients (Peleg et al., 2008a)....
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...There are a number of reviews that provide comprehensive information on antibiotic resistance mechanisms and clinical aspects of A. baumannii infection (Chopra et al., 2008; Peleg et al., 2008a; Vila & Pachón, 2008; Fishbain & Peleg, 2010; Gordon & Wareham, 2010) ....
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1,558 citations
"Acinetobacter baumannii: Human infe..." refers background in this paper
...…that persists on contaminated hospital equipment or by contact with healthcare personnel that have been exposed to the organism through contact with a colonized patient (Maragakis et al., 2004; Crnich et al., 2005; Dijkshoorn et al., 2007; Asensio et al., 2008; Rodrı́guez-Baño et al., 2009)....
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...baumannii results from colonization of the airway via environmental exposure, which is followed by the development of pneumonia (Dijkshoorn et al., 2007)....
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...It is thought that ventilator-associated pneumonia caused by A. baumannii results from colonization of the airway via environmental exposure, which is followed by the development of pneumonia (Dijkshoorn et al., 2007)....
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...baumannii that persists on contaminated hospital equipment or by contact with healthcare personnel that have been exposed to the organism through contact with a colonized patient (Maragakis et al., 2004; Crnich et al., 2005; Dijkshoorn et al., 2007; Asensio et al., 2008; Rodrı́guez-Baño et al., 2009)....
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