Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
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Cites background from "Actions of Caffeine in the Brain wi..."
...These neurons also express dopamine D2 receptors and it is abundantly clear that the two receptors interact in binding assays (Ferré et al., 1991), on signal transduction (Kull et al., 1999), and behaviorally (Fink et al., 1992; Fredholm et al., 1999; Svenningsson et al., 1999b)....
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1,551 citations
Cites background from "Actions of Caffeine in the Brain wi..."
...…of Drugs of Abuse As discussed above, adenosine is centrally involved in the actions of caffeine, which is a relatively nonselective adenosine receptor antagonist, and this pharmacological action is largely responsible for the effects of caffeine on the central nervous system (Fredholm et al 1999)....
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...The pharmacological actions of caffeine, which is the most widely used psychoactive drug in the world, are largely attributable to its activity as an adenosine receptor antagonist ( Fredholm et al 1999 )....
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...The pharmacological actions of caffeine, which is the most widely used psychoactive drug in the world, are largely attributable to its activity as an adenosine receptor antagonist (Fredholm et al 1999)....
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"Actions of Caffeine in the Brain wi..." refers background in this paper
...interpreted as “punishment” (Schultz et al., 1997)....
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...The neurons were suggested to provide information about appetitive stimuli, but not about aversive stimuli, which might mean that the absence of an expected reward is interpreted as “punishment” (Schultz et al., 1997)....
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...According to the model of Schultz et al. (1997) signaling via the dopaminergic neurons would provide a type of general value-related information that only provides a basis for decisions about specific actions if combined with specific information about different types of stimuli....
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2,798 citations
"Actions of Caffeine in the Brain wi..." refers background in this paper
...It was soon realized that this could best be explained if the electrical stimulation of these brain areas activated brain circuitry relevant to the pursuit of natural incentives (Olds and Milner, 1954; Olds, 1956)....
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