Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
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Cites background from "Activated T cells regulate bone los..."
...Typically, fusions with immunoglobulin or (Lam et al., 2000), and acts independently to induce leucine zipper oligomerization domains are used to osteoclast development and bone resorption restricted achieve high-level activity of the soluble ligand or recepto localized sites of injection in RANK/RANKL-deficient tor (Haak-Frendscho et al., 1994; Walczak et al., 1999). mice (Li et al., 2000)....
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...TNF both have been widely used for both research and clinical synergizes with RANKL to promote osteoclastogenesis applications....
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...Estrogen inducesgranules after activation, produces various inflammaOPG, potentially explaining postmenopausal osteopo-tory cytokines, chemokines such as MCP-1, procoagurosis and the protective effects of estrogens on bone.lant activity, adhesion molecules, matrix-degrading metEstrogen deficiency, at least in experimental animals, isalloproteinases, and inflammatory lipid mediators. also associated with enhanced RANKL and TNF produc-Atherosclerotic plaques formed in this milieu are popution by T cells (Cenci et al., 2000).lated by lipid-laden macrophages derived from MCP-1In addition to their critical function in bone homeosta-recruited blood-borne monocytes....
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...Struccell-mediated regulation of osteoclastogenesis by signalling cross-tural basis for self-association and receptor recognition of human talk between RANKL and IFN-g....
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...Deletion of RANKL or RANK results in the absence of all peripheral and mesenteric lymph nodes 2000) (Table 1)....
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References
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"Activated T cells regulate bone los..." refers background in this paper
...We show that: (1) p66 is serine phosphorylated upon treatment with hydrogen peroxide (H2O2) or irradiation with ultraviolet light; (2) ablation of p66 enhances cellular resistance to apoptosis induced by H2O2 or ultraviolet light; (3) a serinephosphorylation defective mutant of p66 cannot restore the normal stress response in p66 cells; (4) the p53 and p21 stress response is impaired in p66 cells; (5) p66 mice have increased resistance to paraquat and a 30% increase in life span....
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5,050 citations
"Activated T cells regulate bone los..." refers background in this paper
...We show that: (1) p66 is serine phosphorylated upon treatment with hydrogen peroxide (H2O2) or irradiation with ultraviolet light; (2) ablation of p66 enhances cellular resistance to apoptosis induced by H2O2 or ultraviolet light; (3) a serinephosphorylation defective mutant of p66 cannot restore the normal stress response in p66 cells; (4) the p53 and p21 stress response is impaired in p66 cells; (5) p66 mice have increased resistance to paraquat and a 30% increase in life span....
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3,265 citations
"Activated T cells regulate bone los..." refers background in this paper
...gif" NDATA ITEM> ]> Bone remodelling and bone loss are controlled by a balance between the tumour necrosis factor family molecule osteoprotegerin ligand (OPGL) and its decoy receptor osteoprotegerin (OPG...
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2,821 citations
"Activated T cells regulate bone los..." refers background in this paper
...To further explore the effect of spontaneously activated T cells on bone metabolism, we adoptively transferred ctla4 p/- or ctla4 -/- bone marrow cells into lymphocyte-deficient rag1 -/- mic...
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2,742 citations
"Activated T cells regulate bone los..." refers background in this paper
...To evaluate whether T-cell activation and expression of OPGL affect bone physiology in vivo , we explored the phenotype of ctla4 -/- mice, in which T cells are spontaneously activate...
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