Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia.
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Cites background from "Activation of Akt is associated wit..."
...In another analysis of primary B-ALL samples, patients with increased phosphorylated AKT at diagnosis had a significantly inferior response to steroid-containing induction therapy and had decreased overall and relapse-free survival (115)....
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References
5,505 citations
"Activation of Akt is associated wit..." refers background in this paper
...Akt binds to phosphatidylinositol-3,4,5-triphosphate on the plasma membrane where Akt is activated by phosphorylation at threonine308 (T308) and serine473 (S473) residues....
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...Antibodies against Akt and PAkt on S473 and HRP-linked secondary antibody were purchased from Cell Signaling Technology Inc. (Irvine, CA) and antibodies against b-actin and Myc tag from Santa Cruz Biotechnology Inc. and Millipore Corp. (Billerica, MA), respectively....
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...30-Phosphoinositide-dependent kinase 1 phosphorylates the activation loop of Akt at T308, although the mammalian target of rapamycin complex 2 phosphorylates Akt at the hydrophobic motif S473 [7]....
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1,811 citations
"Activation of Akt is associated wit..." refers background in this paper
...We assume that other pathways aside from P-glycoprotein play an important role in MDR in Nalm-6/Akt, such as expression of another ATP-binding cassette transporter, inhibition of BAD, inhibition of Caspase-9, activation of NF-kB, inhibition of p53, and so forth [6,24]....
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...Activation of the PI3K/Akt pathway induces activation of nuclear factor-kB and Bcl-2 and inhibition of Bcl-2 antagonist of cell death (BAD), Caspase-9 and p53 [6]....
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...The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is a prototypic survival pathway that plays a central role in diverse cellular functions including insulin metabolism, protein synthesis, proliferation, and apoptosis [5,6]....
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985 citations
"Activation of Akt is associated wit..." refers background in this paper
...P-glycoprotein is a member of ATP-binding cassette transporters that extract antitumor drugs from cytoplasm and which reduce intracellular drug concentrations to sub-lethal levels [20,21]....
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...The expression of P-glycoprotein, encoded by the MDR1 gene, is often associated with MDR in tumor cells [20,27]....
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...In patients with leukemias, lymphomas, and multiple myeloma, P-glycoprotein expression, which is very low at presentation, is occasionally enhanced during administration of long-term chemotherapy or when the disease recurs [20]....
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949 citations
"Activation of Akt is associated wit..." refers background in this paper
...Furthermore, murine models of Akt activation have shown that constitutively active Akt causes myeloproliferative disease [30], promotes drug resistance, and shortens tumor-free survival [25]....
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767 citations
"Activation of Akt is associated wit..." refers background in this paper
...The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is a prototypic survival pathway that plays a central role in diverse cellular functions including insulin metabolism, protein synthesis, proliferation, and apoptosis [5,6]....
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...The PI3K/Akt signaling pathway controls the expression and function of many proteins that are necessary for cell survival, growth, and anti-apoptosis [5]....
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