Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia.
Citations
223 citations
Cites background from "Activation of Akt is associated wit..."
...…of mutational loss of PTEN and increased AKT1 phosphorylation with primary glucocorticoid resistance in the clinic (Bandapalli et al., 2013; Morishita et al., 2012) and the availability of PI3K-AKT specific inhibitors in clinical trials for the treatment of human cancer, prompted us to…...
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...These results, together with the association of mutational loss of PTEN and increased AKT1 phosphorylation with primary glucocorticoid resistance in the clinic (Bandapalli et al., 2013; Morishita et al., 2012) and the availability of PI3K-AKT specific inhibitors in clinical trials for the treatment of human cancer, prompted us to analyze the mechanistic role of AKT1 in the control of glucocorticoid resistance in T-ALL....
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127 citations
Cites background from "Activation of Akt is associated wit..."
...Vincristine Peripheral neurotoxicity Ak t (205, 326), p38 MAPK (96), P-gp, survivin (283)...
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112 citations
Cites background from "Activation of Akt is associated wit..."
...Moreover, in a retrospective study, pAKT was associated to poor overall survival [42]....
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92 citations
Cites background from "Activation of Akt is associated wit..."
...Activation of Akt was associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia.(26) The PI3k/Akt pathway was involved in P-gp-associated survivin transcription activity in the multidrug-resistant MCF-7 breast cancer cells....
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References
51 citations
"Activation of Akt is associated wit..." refers result in this paper
...A similar result has been reported for a chronic myeloid leukemia cell line: K562 cells [19]....
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48 citations
"Activation of Akt is associated wit..." refers background in this paper
...In a T-ALL cell line, CEM cells, P-glycoprotein expression was increased more in drug-resistant cells than in wild-type cells [17,18]....
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...Then flow cytometric analysis was performed [17,22]....
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44 citations
"Activation of Akt is associated wit..." refers methods in this paper
...) for 24 hours, flow cytometric analysis was conducted of Annexin V-allophycocyanin (BD Biosciences) stained samples, as reported by other investigators [23]....
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38 citations
Additional excerpts
...Although a similar condition has been shown in several acute lymphoblastic leukemia (ALL) cell lines such as Reh and Nalm-24 [13,14], the pathological significance of activation of the PI3K/Akt signaling pathway has not been shown sufficiently in a clinical setting....
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37 citations
"Activation of Akt is associated wit..." refers background in this paper
...1Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700- 8558, Japan; 2Department of Pediatrics, Toyonaka Municipal Hospital, Toyonaka, Japan; 3Department of Hematology and Oncology, Kobe Children’s Hospital, Kobe, Japan Grant sponsor: The Japanese Ministry of Health, Labor and Welfare; Grant sponsor: The Japanese Ministry of Education, Culture, Sports, Science and Technology....
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...This hospital plays a central role in medical care for severely ill children with hematologic malignancies in western Japan....
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...The patients enrolled in JACLS ALL02 were stratified provisionally into three groups [standard risk (SR), high risk (HR), and extremely high risk (ER)] and treated accordingly [15]....
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...*Correspondence to: Hirokazu Tsukahara, MD, PhD, Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan....
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...All these drugs have been incorporated into the induction protocols for pediatric B-pre ALL in Japan [15]....
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