Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
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TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Drug-induced liver injury.
Lafaine M. Grant,Don C. Rockey +1 more
TL;DR: Studies in the peer-reviewed literature in the last 2 years, focusing on the diagnosis, prediction and management of DILI, can help with predicting and avoiding DILi in clinical practice and provide the foundation for ongoing research.
Journal ArticleDOI
Liver Failure due to Acute Viral Hepatitis (A-E).
TL;DR: Although numbers in Western European countries are decreasing rapidly, reliable diagnostic screening for hepatitis A-E is necessary to identify the etiology and to determine those most at risk of developing ALF.
Journal ArticleDOI
Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience in the United States
TL;DR: This review will discuss the DILIN expert opinion process, its strengths and weaknesses, psychometric performance and future.
Journal ArticleDOI
Drug induced liver injury: accuracy of diagnosis in published reports.
TL;DR: Alternative diagnoses are common in primarily suspected DILI cases and should be excluded early in future cases, requiring a thorough clinical and causality assessment.
Journal ArticleDOI
Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum
Jia-bo Wang,Zhi-Jie Ma,Zhi-Jie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yan-ling Zhao,Jingyuan Song,Zhao-fang Bai,Yaming Zhang,Ping Zhang,Na Li,Ya-kun Meng,Qi Li,Lu-shan Qin,Guangju Teng,Jun-ling Cao,Bao-Sen Li,Shilin Chen,Yonggang Li,Zheng-sheng Zou,Honghao Zhou,Xiao-He Xiao +22 more
TL;DR: Screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements and excludes Toxin (heavy metals, pesticides, and mycotoxins) contamination.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
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Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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