Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
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TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Posttransplantation hepatitis E: transfusion-transmitted hepatitis rising from the ashes.
Audrey Coilly,Stéphanie Haim-Boukobza,Bruno Roche,Teresa Antonini,Anthony Pause,Camelia Mokhtari,Aymeric Becq,Hussein Farahmand,L. Hauser,Jean-Charles Duclos-Vallée,Didier Samuel,René Adam,Anne-Marie Roque-Afonso +12 more
TL;DR: In developed countries, acute hepatitis E virus infections are increasingly reported mostly due to zoonotic genotypes 3 and 4 strains, and risk factors for these sporadic cases include consumption of raw or undercooked infected meat or direct contact with infected animals.
Journal ArticleDOI
Diagnosis and Management of Drug-Induced Liver Injury (DILI) in Patients with Pre-Existing Liver Disease.
Rolf Teschke,Gaby Danan +1 more
TL;DR: A diagnostic approach using RUCAM applied to suspected DILI cases includes clinical and biological markers of pre-existing liver diseases and would determine whether drugs or underlying liver diseases caused the LT abnormalities or the new symptoms.
Journal ArticleDOI
Drug induced liver injury with analysis of alternative causes as confounding variables.
Rolf Teschke,Gaby Danan +1 more
TL;DR: Patients included in series of suspected DILI are at high risk of not having DILi, whereby alternative causes may confound the DilI diagnosis.
Journal ArticleDOI
Hepatitis E: current status.
TL;DR: In this comprehensive review, the current knowledge on HEV infection is summarized and the possibility of the disease becoming chronic in transplant patients, the Immunocompromised in general, and even in patients with previous liver disease who are immunocompetent are summarized.
Journal ArticleDOI
Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study
Antonios Douros,Elisabeth Bronder,Frank Andersohn,Andreas Klimpel,Reinhold Kreutz,Edeltraut Garbe,Edeltraut Garbe,Juliane Bolbrinker +7 more
TL;DR: This case series corroborates known risks for ayurvedic herbs, supports the suspected association between Valeriana use and liver injury, and indicates a hepatotoxic potential for herbs such as Pelargonium sidoides, Hypericum perforatum or Mentha piperita that were rarely associated with liver injury before.
References
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Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
Journal ArticleDOI
Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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