Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Timothy Davern,Naga Chalasani,Robert J. Fontana,Paul H. Hayashi,Petr Protiva,David E. Kleiner,Ronald E. Engle,Hanh Nguyen,Suzanne U. Emerson,Robert H. Purcell,Hans L. Tillmann,Jiezhun Gu,Jose Serrano,Jay H. Hoofnagle +13 more
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TLDR
HEV infection contributes to a small but important proportion of cases of acute liver injury that are suspected to be drug induced, andSerologic testing for HEV infection should be performed, particularly if clinical features are compatible with acute viral hepatitis.About:
This article is published in Gastroenterology.The article was published on 2011-11-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Hepatitis E & Viral hepatitis.read more
Citations
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Journal ArticleDOI
Herb-Drug Interactions and Hepatotoxicity.
Mohammad K. Parvez,Vikas Rishi +1 more
TL;DR: Herb-drug interaction related morbidity is thus an emerging serious public health issue with broad implications for clinicians, pharmaceutical industries and health authorities.
Journal ArticleDOI
The epidemiology of hepatitis E virus infections in developed countries and among immunocompromised patients
TL;DR: This review will focus on emerging evidence of HEV infection as an under-recognized pathogen in Europe, the USA and other industrialized countries and recent reports of acute and chronic HEV infections among transplant recipients and other immunocompromised individuals including HIV/AIDS patients.
Journal ArticleDOI
Transfusion-transmitted hepatitis E in a misleading context of autoimmunity and drug-induced toxicity
Stéphanie Haim-Boukobza,Marie-Pierre Férey,Anne-Laure Vétillard,Asma Jeblaoui,Elisabeth Pélissier,Gilles Pelletier,Laurent Teillet,Anne-Marie Roque-Afonso +7 more
TL;DR: The case of a patient with acute hepatitis while receiving potentially hepatotoxic medications for autoimmune disorders, with low-level autoimmune markers and negative "standard" viral markers; it was finally determined that he was suffering from transfusion-transmitted hepatitis E.
Journal ArticleDOI
Laboratory-based surveillance for hepatitis E virus infection, United States, 2005-2012.
Jan Drobeniuc,Tracy Greene-Montfort,Ngoc-Thao Le,Tonya Mixson-Hayden,Lilia Ganova-Raeva,Chen Dong,Ryan T. Novak,Umid M. Sharapov,Rania A. Tohme,Eyasu H. Teshale,Saleem Kamili,Chong-Gee Teo +11 more
TL;DR: Clinicians should consider this virus in the differential diagnosis of hepatitis, regardless of patient travel history, wherever the patient has travelled in the world.
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Review article: hepatitis E—a concise review of virology, epidemiology, clinical presentation and therapy
Mhairi C Donnelly,Linda Scobie,Claire Crossan,Harry R. Dalton,Peter C. Hayes,Kenneth J. Simpson +5 more
TL;DR: Chronic HEV infection is now recognised, and in transplant recipients this may lead to cirrhosis and organ failure.
References
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Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
TL;DR: In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.
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Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
Nassim Kamar,Janick Selves,Jean-Michel Mansuy,Leila Ouezzani,Jean-Marie Péron,Joelle Guitard,Olivier Cointault,Laure Esposito,Florence Abravanel,Marie Danjoux,Dominique Durand,Jean-Pierre Vinel,Jacques Izopet,Lionel Rostaing +13 more
TL;DR: The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Journal ArticleDOI
A novel virus in swine is closely related to the human hepatitis E virus
Xiang-Jin Meng,Robert H. Purcell,Patrick G. Halbur,James R. Lehman,Dale M. Webb,Tatiana S. Tsareva,Joseph S. Haynes,Brad J. Thacker,Suzanne U. Emerson +8 more
TL;DR: The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.
Journal ArticleDOI
Hepatitis E virus.
TL;DR: Hepatitis E virus is an enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis in many countries of Asia and Africa but only rarely causes disease in more industrialised countries.
Journal ArticleDOI
Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States
Naga Chalasani,Robert J. Fontana,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Paul B. Watkins,Timothy J. Davern,Jose Serrano,Hongqiu Yang,James Rochon +9 more
TL;DR: This report summarizes the causes, clinical features, and outcomes from the first 300 patients enrolled in a prospective study to recruit patients with suspected idiosyncratic drug-induced liver injury and create a repository of biological samples for analysis.
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