Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia–reperfusion injury
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...…pharmacological depletion strategies, results in reduced neutrophil recruitment and associated injury after I/R (Caldwell et al., 2005; Horie et al., 1999; Martin et al., 2010; Osman et al., 2009; Park et al., 2002; Sharma et al., 2010; Uchida et al., 2010; Yang et al., 2009; Zwacka et al., 1997)....
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...T cellmediated recruitment of neutrophils has been attributed to T cell secretion of IL-17 (Caldwell et al., 2005; Sharma et al., 2010), but other T-cell-derived factors, for example, IL-1, TNFa, likely also play a role....
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...As in other tissues, A2AAR activation protects against inflammatory tissue damage in the lung caused by IRI[90,112,113]....
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...Evidence for the specific cell types involved in this A2AAR-mediated response has been obtained using a mouse model of lung IRI in which ATL313 inhibited lung injury and reduced CD4 + T-cell activation and neutrophil recruitment[90]....
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...Levels of inflammatory cytokines and chemokines (TNF, IL-17, KC, MCP-1, MIP-1, and RANTES) in BALF were also lower in the absence of neutrophils or CD4 + T cells, but could only be further reduced by ATL313 in neutrophil-depleted mice, indicating that suppression of neutrophil activity may be secondary to ligation of A2AARs on CD4 + T cells[90]....
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...Activation of the A2AAR has been found to protect against inflammatory damage caused by ischaemia and reperfusion in a number of tissues including liver[88], kidney[89], lung[90], and heart[91]....
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"Adenosine A2A receptor activation o..." refers background in this paper
...IL-17, produced largely by CD4þnatural killer T cells and T helper 17 cells, is a key cytokine for the recruitment, activation, and migration of neutrophils.(24) Thus, reduced levels of KC (a potent neutrophil chemokine) and MPO (ie, neutrophil infiltration) in the ATL313-treated groups are likely secondary to the inactivation of CD4þ T cells....
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"Adenosine A2A receptor activation o..." refers result in this paper
...This supports prior studies suggesting that neutrophils may also be a source of IL-17.(25) However,...
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...This supports prior studies suggesting that neutrophils may also be a source of IL-17....
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