Adenosine signaling during acute and chronic disease states
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...Nevertheless, adenosine accumulation can lead to chronic inflammation and diseases.(10) Surprisingly, using millimolar concentrations (1–5mM), we observed that exogenous adenosine alone was able to induce NLRP3 inflammasome activation....
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...Sustained high levels of adenosine can, however, turn harmful by triggering immune suppression or by activating unremitting wound-healing [17, 18]....
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References
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"Adenosine signaling during acute an..." refers background in this paper
...Anti-inflammatory properties of this receptor have been demonstrated in T cells [44], NK T cells [45, 46], invariant NK T cells [46], macrophages [47], neutrophils [48], dendritic cells [49], and T regulatory cells [50] where ADOR2A signaling is associated with inhibition of proliferation, inflammatory cytokine production and increased production of anti-inflammatory cytokines....
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1,603 citations
"Adenosine signaling during acute an..." refers background in this paper
...In acute injury settings, this hypoxic adenosine response activates pathways that promote tissue adaptation during hypoxia [1]....
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...sis involve severe levels of hypoxia [1]....
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1,303 citations
"Adenosine signaling during acute an..." refers background in this paper
...Please see the following reviews for more information on the functions of these receptors in acute and chronic disease processes [25, 42, 43]....
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"Adenosine signaling during acute an..." refers background in this paper
...This receptor is coupled to G-stimulatory alpha subunits to increase cAMP levels in the cell [34]....
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...Increases in extracellular adenosine in turn elicit various responses on target cells by engaging cell surface adenosine receptors [33, 34]....
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