Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study.
Fermín Sánchez-Guijo,Mariano García-Arranz,Miriam López-Parra,Pablo Monedero,Carmen Mata-Martínez,Arnoldo Santos,Víctor Sagredo,José Manuel Alvarez-Avello,José Eugenio Guerrero,César Pérez-Calvo,Miguel Vicente Sanchez-Hernandez,José Luis Del-Pozo,Enrique J. Andreu,María Eugenia Fernández-Santos,María Eugenia Fernández-Santos,Bárbara Soria-Juan,Luis Hernandez-Blasco,Etelvina Andreu,José M. Sempere,Agustín G. Zapata,José M. Moraleda,Bernat Soria,Francisco Fernández-Avilés,Damián García-Olmo,Felipe Prosper +24 more
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TLDR
Treatment with intravenous administration of AT-MSC in 13 severe COVID-19 pneumonia under mechanical ventilation in a small case series did not induce significant adverse events and was followed by clinical and biological improvement in most subjects.About:
This article is published in EClinicalMedicine.The article was published on 2020-07-10 and is currently open access. It has received 122 citations till now. The article focuses on the topics: Mechanical ventilation & Interquartile range.read more
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Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series.
Seyed-Mohammad Reza Hashemian,Rasoul Aliannejad,Morteza Zarrabi,Masoud Soleimani,Masoud Soleimani,Massoud Vosough,Seyedeh-Esmat Hosseini,Seyedeh-Esmat Hosseini,Hamed Hossieni,Saeid Heidari Keshel,Zeinab Naderpour,Ensiyeh Hajizadeh-Saffar,Elham Shajareh,Hamidreza Jamaati,Mina Soufizomorrod,Naghmeh Khavandgar,Hediyeh Alemi,Aliasghar Karimi,Neda Pak,Negin Hossieni Rouzbahani,Negin Hossieni Rouzbahani,Masoumeh Nouri,Majid Sorouri,Ladan Kashani,Hoda Madani,Nasser Aghdami,Mohammad Vasei,Hossein Baharvand,Hossein Baharvand +28 more
TL;DR: In this article, the safety, feasibility, and tolerability of the multiple infusions of high dose MSCs, which originated from the placenta and umbilical cord, in critically ill COVID-19-induced ARDS patients were presented.
Journal ArticleDOI
Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19.
TL;DR: In this paper, the authors highlight the major guidelines and differences in ADSC processing meeting the current good manufacturing practices (cGMP) and the cellular therapy-related policies and present specific insights on standardization of ADSCs proceeding at different check points.
Journal ArticleDOI
Stem cell therapy for COVID-19, ARDS and pulmonary fibrosis.
Zhongwen Li,Shuaishuai Niu,Baojie Guo,Tingting Gao,Lei Wang,Yukai Wang,Liu Wang,Yuanqing Tan,Jun Wu,Jie Hao +9 more
TL;DR: Of all the stem cell therapies touted for COVID‐19 treatment, mesenchymal stem cells (MSCs) or MSC‐like derivatives have been the most promising in preclinical studies and clinical trials so far.
Journal ArticleDOI
Evaluation of the safety and efficacy of using human menstrual blood‐derived mesenchymal stromal cells in treating severe and critically ill COVID‐19 patients: An exploratory clinical trial
Xiaowei Xu,Wanli Jiang,Lijun Chen,Zhenyu Xu,Qiang Zhang,Mengfei Zhu,Peng Ye,Hang Li,Liang Yu,Xiaoyang Zhou,Chenliang Zhou,Xiaobei Chen,Xiaoqin Zheng,Kaijin Xu,Hongliu Cai,Shufa Zheng,Wubian Jiang,Xiaojun Wu,Dong Li,Lu Chen,Qingqing Luo,Yingyan Wang,Jingjing Qu,Yifei Li,Wendi Zheng,Yingan Jiang,Lingling Tang,Charlie Xiang,Lanjuan Li +28 more
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Adipose-Derived Stem Cells Secretome and Its Potential Application in “Stem Cell-Free Therapy”
TL;DR: In this article, the authors focus on the current state of knowledge on the use of the ASCs secretome in stem cell-free therapy and propose a biobanking approach for ASC-derived exosomes (ASC-exos).
References
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TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
Massimo Dominici,K. Le Blanc,Ingo Mueller,I. Slaper-Cortenbach,Frank C. Marini,Diane S. Krause,Robert J. Deans,Armand Keating,Darwin J. Prockop,Edwin M. Horwitz +9 more
TL;DR: The Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposes minimal criteria to define human MSC, believing this minimal set of standard criteria will foster a more uniform characterization of MSC and facilitate the exchange of data among investigators.
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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
TL;DR: The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.
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COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta,Daniel F. McAuley,Michael Brown,Emilie Sanchez,Rachel Tattersall,Rachel Tattersall,Jessica J Manson +6 more
TL;DR: Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.
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Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
Giacomo Grasselli,Giacomo Grasselli,Alberto Zangrillo,Alberto Zanella,Alberto Zanella,Massimo Antonelli,Massimo Antonelli,Luca Cabrini,Antonio Castelli,Danilo Cereda,Antonio Coluccello,Giuseppe Foti,Roberto Fumagalli,Giorgio Antonio Iotti,Nicola Latronico,Luca Lorini,Stefano Merler,Giuseppe Natalini,Alessandra Piatti,Marco Ranieri,Anna Mara Scandroglio,Enrico Storti,Maurizio Cecconi,Antonio Pesenti,Antonio Pesenti +24 more
TL;DR: Patients with coronavirus disease 2019 (COVID-19) requiring treatment in an intensive care unit (ICU) in the Lombardy region of Italy were characterized, including data on clinical management, respiratory failure, and patient mortality.
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