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Adipose tissue metabolism: influence of periodicity of eating and diet composition.

01 May 1970-Vol. 29, Iss: 3, pp 1294-1301
About: The article was published on 1970-05-01 and is currently open access. It has received 103 citations till now. The article focuses on the topics: Adipose tissue & Appetite.
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Journal ArticleDOI
TL;DR: The modest caloric intake of these men and the lack of correlation between percent body fat and total calories suggest that calorie differences are not the major cause of the variations in obesity in these men.

320 citations

Journal ArticleDOI
TL;DR: The available evidence suggests that in the chicken, and presumably other avian species, fatty acids are synthesized in liver and are transported as triglycerides in the plasma low-density lipoproteins to the adipose tissue for storage.

291 citations

Journal ArticleDOI
TL;DR: Man might, thus, be uniquely limited in the capacity to dispose of extra carbohydrate in the sedentary state, which might speculatively be thought to be an explanation for a carbohydrate excess syndrome in thesedentary state that may well increase the risk for obesity, hyperinsulinemia, and diabetes mellitus.
Abstract: Recent information indicates that the capacity of man to store carbohydrate energy by transformation into fatty acids synthetized de novo is very limited in adipose tissue as well as in liver and intestine. This seems to be in contrast to other species such as the rat where de novo fatty acid synthesis can be induced to a high capacity of glucose removal. This leaves man with a limited capacity to store excess carbohydrate. The remaining possibilities are both the main glycogen stores in liver and in muscle. The latter is by far the largest. The capacity of muscle to assimilate glucose is dependent on its glycogen content that in turn is dependent on previous glycogen depletion to supply energy for muscle contraction. Man might, thus, be uniquely limited in the capacity to dispose of extra carbohydrate in the sedentary state. This might speculatively be thought to be an explanation for a carbohydrate excess syndrome in the sedentary state that may well increase the risk for obesity, hyperinsulinemia, and diabetes mellitus. The logical treatment for such a syndrome then is either a decreased intake of energy as carbohydrate or an increased disposal of carbohydrate energy by exercise. Exercise has, indeed, been shown to have such effects both after physical training programs and, perhaps more pertinent to the question, during a few days after a single exercise bout that has consumed a large amount of muscle glycogen.

227 citations

Journal ArticleDOI
TL;DR: Hamsters' nocturnal rhythms of eating and drinking were remarkably stable in the face of all the experimental manipulations, and hamsters, as well as rats, were quite effective in compensating for changes in diet density; a 1:1 dilution of a liquid diet produced a prompt doubling in the volume of diet ingested.

225 citations

Journal ArticleDOI
TL;DR: It is suggested that individuals with a high VO2 max (such as aerobically trained athletes) show a greater caloric expenditure after eating, particularly after a large meal, than doindividuals with a lowVO2 max.
Abstract: The relationship between size of a mixed, liquid meal and the thermic effect of food (TEF) was studied in two groups of nonobese male subjects differing in maximum aerobic capacity (VO2 max) A design using repeated measures was chosen in which each subject received each meal (water, 500 kcal, 1000 kcal, 1500 kcal) on a different morning TEF was measured by indirect calorimetry for three hours following each meal and was found to increase systematically, in a nonlinear fashion, as meal size was increased Subjects with a high VO2 max responded to the two higher calorie meals with a greater TEF than did subjects with a low VO2 max They also showed a greater increase in TEF for any given increase in meal size This study establishes a precise relationship between meal size and the thermic effect of food It also identifies an important variable, VO2 max, in determination of the individual thermic response to food These findings suggest that individuals with a high VO2 max (such as aerobically trained athletes) show a greater caloric expenditure after eating, particularly after a large meal, than do individuals with a low VO2 max A high thermic response to food could be beneficial in body weight homeostasis

104 citations